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| Author | : Stanley E. Lazic |
| Publisher | : Cambridge University Press |
| Total Pages | : 429 |
| Release | : 2016-12-08 |
| Genre | : Family & Relationships |
| ISBN | : 1107074290 |
A guide to designing lab-based biological experiments that have low bias, high precision and widely applicable results.
| Author | : David J. Glass |
| Publisher | : CSHL Press |
| Total Pages | : 211 |
| Release | : 2007 |
| Genre | : Biology |
| ISBN | : 0879697350 |
The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as “assumption controls†and “experimentalist controls†. Furthermore, there are sections on establishing the experimental system, which include performing critical “system controls†. Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.
| Author | : Gerry P. Quinn |
| Publisher | : Cambridge University Press |
| Total Pages | : 851 |
| Release | : 2002-03-21 |
| Genre | : Nature |
| ISBN | : 1139432893 |
An essential textbook for any student or researcher in biology needing to design experiments, sample programs or analyse the resulting data. The text begins with a revision of estimation and hypothesis testing methods, covering both classical and Bayesian philosophies, before advancing to the analysis of linear and generalized linear models. Topics covered include linear and logistic regression, simple and complex ANOVA models (for factorial, nested, block, split-plot and repeated measures and covariance designs), and log-linear models. Multivariate techniques, including classification and ordination, are then introduced. Special emphasis is placed on checking assumptions, exploratory data analysis and presentation of results. The main analyses are illustrated with many examples from published papers and there is an extensive reference list to both the statistical and biological literature. The book is supported by a website that provides all data sets, questions for each chapter and links to software.
| Author | : Michael H. Herzog |
| Publisher | : Springer |
| Total Pages | : 146 |
| Release | : 2019-08-13 |
| Genre | : Science |
| ISBN | : 3030034992 |
This open access textbook provides the background needed to correctly use, interpret and understand statistics and statistical data in diverse settings. Part I makes key concepts in statistics readily clear. Parts I and II give an overview of the most common tests (t-test, ANOVA, correlations) and work out their statistical principles. Part III provides insight into meta-statistics (statistics of statistics) and demonstrates why experiments often do not replicate. Finally, the textbook shows how complex statistics can be avoided by using clever experimental design. Both non-scientists and students in Biology, Biomedicine and Engineering will benefit from the book by learning the statistical basis of scientific claims and by discovering ways to evaluate the quality of scientific reports in academic journals and news outlets.
| Author | : Robert E. Kohler |
| Publisher | : University of Chicago Press |
| Total Pages | : 341 |
| Release | : 2010-11-15 |
| Genre | : Science |
| ISBN | : 0226450112 |
What is it like to do field biology in a world that exalts experiments and laboratories? How have field biologists assimilated laboratory values and practices, and crafted an exact, quantitative science without losing their naturalist souls? In Landscapes and Labscapes, Robert E. Kohler explores the people, places, and practices of field biology in the United States from the 1890s to the 1950s. He takes readers into the fields and forests where field biologists learned to count and measure nature and to read the imperfect records of "nature's experiments." He shows how field researchers use nature's particularities to develop "practices of place" that achieve in nature what laboratory researchers can only do with simplified experiments. Using historical frontiers as models, Kohler shows how biologists created vigorous new border sciences of ecology and evolutionary biology.
| Author | : Simon T. Bate |
| Publisher | : Cambridge University Press |
| Total Pages | : 327 |
| Release | : 2014-03-13 |
| Genre | : Computers |
| ISBN | : 1107030781 |
This book will provide scientists with a better understanding of statistics, improving their decision-making and reducing animal use.
| Author | : Jenny E. Sabin |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2018 |
| Genre | : Architecture and biology |
| ISBN | : 9781138783966 |
Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Foreword: Reinventing Nature -- Acknowledgments -- Part I Design Research in Practice: Methodology and Approach with Historical Precedents and Case Studies -- 1 Bioconstructivisms -- Trans-Disciplinary Research Practice: Contemporary Case Studies -- 2 Design Research in Practice: A New Model -- Part II Design Computation Tools for Architecture and Science: New Tools and Forms -- Introduction to Design Computation Tools for Architecture and Science: New Tools and Forms -- 3 Networking: Elasticity and Branching Morphogenesis -- Comments on the Role of the Matrix -- New Architectural Concerns -- 4 Motility: Adaptive Architecture and Personalized Medicine -- Topologically Free Cells -- Avoiding Biomimicry -- Visualizing in Another Dimension -- Positioning Mechanism -- Newness -- 5 Surface Design: The Mammary Gland as a Model of Architectural Connectivity -- On Geometry and Cellular Mechanics -- Biological Data and Intuition -- Case Study: Understanding Behavioral Rule Sets through Cell Motility -- Case Study: Motility and the Observation of Change -- Case Study: Microfabrication: Spatializing Cell Signaling and Sensing Mechanisms -- 6 BioInspired Materials and Design -- Part III Architectural Prototyping: Human-Scale Material Systems and Big Datascapes -- 7 The New Science of Making -- 8 Matter Design Computation: Biosynthesis and New Paradigms of Making -- Project: Branching Morphogenesis, 2008 -- Project: Ground Substance, 2009 -- Workshop: Nonlinear Systems Biology and Design, 2010 -- Part IV Personalized Architecture and Medicine -- 9 eSkin: BioInspired Adaptive Materials -- 10 myThread Pavilion -- Interview: RE(IN)FORM(ULAT)ING Health Care via Medicine + Creativity -- Conclusion -- Notes on Contributors -- Image Credits -- Index
| Author | : Natalie Kuldell PhD. |
| Publisher | : "O'Reilly Media, Inc." |
| Total Pages | : 293 |
| Release | : 2015-06-22 |
| Genre | : Science |
| ISBN | : 1491907533 |
Today’s synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it. Based on the BioBuilder curriculum, this valuable book provides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories. It also serves as an introduction to the field for science and engineering enthusiasts. Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges. Learn the fundamentals of biodesign and DNA engineering Explore important ethical issues raised by examples of synthetic biology Investigate the BioBuilder labs that probe the design-build-test cycle Test synthetic living systems designed and built by engineers Measure several variants of an enzyme-generating genetic circuit Model "bacterial photography" that changes a strain’s light sensitivity Build living systems to produce purple or green pigment Optimize baker’s yeast to produce ?-carotene
| Author | : Steve McKillup |
| Publisher | : Cambridge University Press |
| Total Pages | : 430 |
| Release | : 2011-11-03 |
| Genre | : Medical |
| ISBN | : 1139502948 |
An understanding of statistics and experimental design is essential for life science studies, but many students lack a mathematical background and some even dread taking an introductory statistics course. Using a refreshingly clear and encouraging reader-friendly approach, this book helps students understand how to choose, carry out, interpret and report the results of complex statistical analyses, critically evaluate the design of experiments and proceed to more advanced material. Taking a straightforward conceptual approach, it is specifically designed to foster understanding, demystify difficult concepts and encourage the unsure. Even complex topics are explained clearly, using a pictorial approach with a minimum of formulae and terminology. Examples of tests included throughout are kept simple by using small data sets. In addition, end-of-chapter exercises, new to this edition, allow self-testing. Handy diagnostic tables help students choose the right test for their work and remain a useful refresher tool for postgraduates.
| Author | : Stephen J. Royle |
| Publisher | : |
| Total Pages | : 200 |
| Release | : 2019 |
| Genre | : Science |
| ISBN | : 9781621822783 |
"Cell biology is becoming an increasingly quantitative field, as technical advances mean researchers now routinely capture vast amounts of data. This handbook is an essential guide to the computational approaches, image processing and analysis techniques, and basic programming skills that are now part of the skill set of anyone working in the field"--
