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Epigenetic Aspects of Chronic Diseases

Epigenetic Aspects of Chronic Diseases
Author: Helmtrud I. Roach
Publisher: Springer Science & Business Media
Total Pages: 246
Release: 2011-04-01
Genre: Medical
ISBN: 1848826443

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Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.


Epigenetics in Human Disease

Epigenetics in Human Disease
Author: Trygve O Tollefsbol
Publisher: Academic Press
Total Pages: 1112
Release: 2018-05-18
Genre: Medical
ISBN: 012812329X

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Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more


Developmental Origins of Health and Disease

Developmental Origins of Health and Disease
Author: Peter Gluckman
Publisher: Cambridge University Press
Total Pages: 542
Release: 2006-04-20
Genre: Medical
ISBN: 9780521847438

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This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.


Epigenetics for Intermediate. The Most Comprehensive Exploration of the Practical, Social and Ethical Impact of DNA on Our Society and Our World

Epigenetics for Intermediate. The Most Comprehensive Exploration of the Practical, Social and Ethical Impact of DNA on Our Society and Our World
Author: Frank Brown
Publisher: Youcanprint
Total Pages: 170
Release: 2021-09-15
Genre: Medical
ISBN:

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You Are About To Develop An Insider Understanding Of Epigenetics, Including Their Relationship With The DNA, Environmental Factors, Human Development And Evolution; Their Role In Human Mental And Physical Health, Including Their Use In The Treating Of Different Conditions And Diseases Along With The Most Current Epigenetic Practices And Research! What started as a broad research focused on combining genetics and developmental biology during the mid-twentieth century has evolved into the field we currently refer to as epigenetics- the mechanism of gene control that can either promote or repress gene expression without altering the genetic coding of the organism. Today, we know that the environment factors and individual lifestyles can have a direct interaction with epigenetic change, which can be reflected at various stages throughout the life of an individual and even in the later generations. You've heard that a mother's exposure to pollution can affect her child's asthma susceptibility, haven't you? No? How about the argument that a child's mental fitness can be (epigenetically) influenced by his/her dad's diet? Epigenetic change, which has nothing to do with the changes to the underlying DNA sequence, does affect how cells read genes and this biological change is influenced by several factors which include environment, lifestyle and health state through a mechanisms including a popular one known as DNA methylation. But what is the relationship between the epigenetic change and physical and physiological conditions as regards to their onset and improvement? How are epigenetic modifications being used to understand our environment, society and increasing human adaptation? How exactly do epigenetic therapies work? How does DNA affect epigenetic changes? How can we exploit epigenetic mechanisms to understand life better and improve it? If you have these and other related questions, this book is for you. More precisely, you will learn: What epigenetics are and their role in developmental psychology The influence of epigenetics at the molecular level and the impact of DNA damage in epigenetic change How epigenetics are studied The functions and consequences of epigenetics, and their specific benefits in mindfulness training, healthy eating and physical activity How genes control the growth and division of cells The role of epigenetic therapy in diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia and many more How epigenetic modifications are used in cancer treatment, and plant and animal evolution How epigenetic mechanisms are used in processes including human adaptation, memory formation, growth and infant neuro-behavior. How epigenetic mechanisms are used in maternal care How environmental chemical exposures affect epigenetics The role of epigenetics in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more The role of environmental exposures in pathophysiology of IPF Modulation of epigenetic marks by environmental exposures How epigenetic regulation affects the immune system …And so much more! So if you've been exposed to the concept of epigenetics as a novel way of understanding disorders, inheritance and evolution and wondered what it's really all about and how it's related with environmental exposure and different therapy practices, this book is all you need! Scroll up and click Buy Now With 1-Click or Buy Now to get started!


Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics
Author: Jose Luis Garcia-Gimenez
Publisher: Academic Press
Total Pages: 698
Release: 2015-12-07
Genre: Science
ISBN: 0128019212

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Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies


Epigenetics in Health and Disease

Epigenetics in Health and Disease
Author: Igor Kovalchuk
Publisher: FT Press
Total Pages: 609
Release: 2012-05-22
Genre: Education
ISBN: 0132599511

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This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.


Molecular mechanisms and physiology of disease

Molecular mechanisms and physiology of disease
Author: Nilanjana Maulik
Publisher: Springer
Total Pages: 510
Release: 2014-05-31
Genre: Medical
ISBN: 1493907069

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In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.


Epigenetics for Beginners and Intermediate (2 Books in 1)

Epigenetics for Beginners and Intermediate (2 Books in 1)
Author: Frank Brown
Publisher: Youcanprint
Total Pages: 330
Release: 2021-09-15
Genre: Medical
ISBN:

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You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes • The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!


Rare Diseases and Orphan Products

Rare Diseases and Orphan Products
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 442
Release: 2011-04-03
Genre: Medical
ISBN: 0309158060

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Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.