Disulfiram And Its Metabolite Diethyldithiocarbamate PDF Download
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Author | : P.K. Gessner |
Publisher | : Springer Science & Business Media |
Total Pages | : 461 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9401123284 |
Download Disulfiram and its Metabolite, Diethyldithiocarbamate Book in PDF, ePub and Kindle
This book is aimed at those in the biomedical community that are interested in the therapeutic applications, pharmacology, biochemistry, toxicology and pharmacokinetics of the title compounds. Recent findings regarding the ability of diethyldithiocarbamate (ditiocarb, Imuthiol®) to delay the progression of HN infections and AIDS, the discovery of its potential as a rescue agent in cancer chemotherapy, and the identification of disulfiram (Antabuse®) regimens that allow alcoholics to achieve abstinence of many months' duration have made writing this book an exciting experience. At the same time the fact that the two drugs differ substantially in their pharmacological effects in spite of their easy interconvertibility has rendered the writing intellec tually challenging. Diethyldithiocarbamate, an agent seemingly less toxic than aspirin, rivals it in the multiplicity and diversity of its pharmacological proper ties. Notable among these are the manyfold potent immunostimulant effects, and though most of these involve effects on T -cells, the mechanism of diethyldithiocarbamate's action remains far from clear. The drug is also a potent chelator of heavy metals and this has led to a number of clinical applications. As might be expected, it inhibits several important enzymes. Further, it is one of the most effective radioprotective agents; it also protects organisms against a variety of toxic agents.
Author | : John Cobby |
Publisher | : |
Total Pages | : 448 |
Release | : 1976 |
Genre | : Biopharmaceutics |
ISBN | : |
Download The Analysis and Pharmacokinetics in Dogs of Diethyldithiocarbamate, a Metabolite of Disulfiram Book in PDF, ePub and Kindle
Author | : Peter Riederer |
Publisher | : Springer Nature |
Total Pages | : 4652 |
Release | : 2022-11-04 |
Genre | : Medical |
ISBN | : 303062059X |
Download NeuroPsychopharmacotherapy Book in PDF, ePub and Kindle
This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.
Author | : Johan H. Strömme |
Publisher | : |
Total Pages | : 72 |
Release | : 1964 |
Genre | : |
ISBN | : |
Download Studies on Metabolism and Biochemical Effects of Tetraethylthiuram Disulphide '(disulfiram)' and Diethyldithiocarbamate Book in PDF, ePub and Kindle
Author | : Avinash De Sousa |
Publisher | : Springer Nature |
Total Pages | : 77 |
Release | : 2019-10-24 |
Genre | : Psychology |
ISBN | : 9813298766 |
Download Disulfiram Book in PDF, ePub and Kindle
This book focuses on the value of supervised Disulfiram therapy, highlighting the many potential and unique benefits of Disulfiram. One of the oldest drugs available for the long-term management of alcohol dependence, Disulfiram remains a viable treatment option for alcohol dependence and has been shown in recent studies to be more successful in treating patients with alcohol dependence than Naltrexone, Topiramate and Acamprosate. It is also useful in dual diagnosis patients and those with co-morbid cocaine and alcohol dependence. Although Disulfiram’s mechanism of action in alcohol dependence was long thought to be its effects as a psychological deterrent, more recent studies point to potential anti-craving effects as well. In dedicated chapters, the book reviews major clinical trials of Disulfiram spanning nearly 60 years, its historical aspects and discovery, side effects, treatment protocols and uses in the context of alcohol dependence. The book also discusses the use of Disulfiram across diverse populations along with monitoring for compliance and various adverse effects that may manifest. Further topics include Disulfiram implant therapy and the role of Disulfiram in the modern long-term pharmacotherapy of alcohol dependence, as well as the role of cognitive behavior therapy in enhancing the effects of Disulfiram and the emerging role of Disulfiram in treating cocaine dependence and pathological gambling. As such, the book offers a “one-stop” comprehensive guide to all aspects of Disulfiram therapy.
Author | : Colin Brewer |
Publisher | : |
Total Pages | : 80 |
Release | : 1992 |
Genre | : Diethyldithiocarbamate |
ISBN | : |
Download Antabuse Book in PDF, ePub and Kindle
Author | : Jan Aaseth |
Publisher | : Academic Press |
Total Pages | : 390 |
Release | : 2016-04-18 |
Genre | : Medical |
ISBN | : 0128030739 |
Download Chelation Therapy in the Treatment of Metal Intoxication Book in PDF, ePub and Kindle
Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds
Author | : Prashant Kesharwani |
Publisher | : Academic Press |
Total Pages | : 432 |
Release | : 2020-05-29 |
Genre | : Business & Economics |
ISBN | : 0128184809 |
Download Drug Discovery Targeting Drug-Resistant Bacteria Book in PDF, ePub and Kindle
Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war
Author | : Wilfried R.F. Notten |
Publisher | : Springer Science & Business Media |
Total Pages | : 169 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642734766 |
Download Health Surveillance of Individual Workers Exposed to Chemical Agents Book in PDF, ePub and Kindle
Early in 1985, a meeting was held to discuss the organization of a work shop in honour of Professor Reinier L. Zielhuis on the occasion of his retirement on November 30,1986. Various themes for such a workshop were considered, but it was Zielhuis himself, who ultimately selected "Health surveillance of individual workers exposed to chemical agents" as the theme of the workshop. Although this topic is of the utmost im portance for occupational health practice, it is also a very difficult one, given our currently limited knowledge on the subject. The choice of this topic is characteristic of Reinier Zielhuis, a scientist and scholar who throughout his career has been deeply concerned with the health and health risks of workers. Because he regards occupational and environmental exposure - including life style - as two aspects of the total exposure to chemical and physical factors, he emphasizes the need to assess the impact of this total exposure on workers' health. The impact of total exposure probably detennines to a large extent the in dividual variability in response. This was the main reason why he selected the above-mentioned topic for the workshop.
Author | : American Psychiatric Association |
Publisher | : American Psychiatric Pub |
Total Pages | : 226 |
Release | : 2018-01-11 |
Genre | : Medical |
ISBN | : 0890426821 |
Download The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder Book in PDF, ePub and Kindle
Alcohol use disorder (AUD) is a major public health problem in the United States. The estimated 12-month and lifetime prevalence values for AUD are 13.9% and 29.1%, respectively, with approximately half of individuals with lifetime AUD having a severe disorder. AUD and its sequelae also account for significant excess mortality and cost the United States more than $200 billion annually. Despite its high prevalence and numerous negative consequences, AUD remains undertreated. In fact, fewer than 1 in 10 individuals in the United States with a 12-month diagnosis of AUD receive any treatment. Nevertheless, effective and evidence-based interventions are available, and treatment is associated with reductions in the risk of relapse and AUD-associated mortality. The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder seeks to reduce these substantial psychosocial and public health consequences of AUD for millions of affected individuals. The guideline focuses specifically on evidence-based pharmacological treatments for AUD in outpatient settings and includes additional information on assessment and treatment planning, which are an integral part of using pharmacotherapy to treat AUD. In addition to reviewing the available evidence on the use of AUD pharmacotherapy, the guideline offers clear, concise, and actionable recommendation statements, each of which is given a rating that reflects the level of confidence that potential benefits of an intervention outweigh potential harms. The guideline provides guidance on implementing these recommendations into clinical practice, with the goal of improving quality of care and treatment outcomes of AUD.