Design And Construction Of Accelerator Based Boron Neutron Capture Therapy Facility With Multiple Treatment Rooms At Southern Tohoku Bnct Research Center PDF Download

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Design And Construction Of Accelerator-Based Boron Neutron Capture Therapy Facility With Multiple Treatment Rooms At Southern Tohoku BNCT Research Center

Design And Construction Of Accelerator-Based Boron Neutron Capture Therapy Facility With Multiple Treatment Rooms At Southern Tohoku BNCT Research Center
Author: Takahiro Kato
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Release: 2017
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ISBN:

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Purpose; To describe the design and construction of an accelerator-based boron neutron capture therapy (AB-BNCT) facility with multiple treatment rooms at the Southern Tohoku BNCT Research Center (STBRC).Materials and Methods; AB-BNCT system at the STBRC is equipped with a cyclotron-based epithermal neutron source (C-BENS), which consists of a cyclotron accelerator (HM-30), a beryllium neutron production target, and a beam shaping assembly (BSA). We developed a remote patient transport system (RPTS) for workers to reduce the work time in the treatment room under the condition of remaining activities just after an irradiation. We studied the feasibility of this system and carefully designed optimum layout to realize patient flow and workflow efficiently.Results; We designed the upside-down Y shaped beamline configuration, in which HM-30 and two treatment rooms are assumed to be located on a top and bottoms, respectively. To reduce the activities caused by thermal neutron, BSA is surrounded by LiF-loaded polyethylene blocks and low-activation concrete. The measured out-of-field thermal and fast neutron dose profiles were in good agreement with calculated ones using MCNPX. It was also confirmed that the RPTS could be operated up to 9 m apart from the RPTS without any problems. Conclusion; We successfully established the environment of BNCT as one of the division of general hospital without sense of incongruity in comparison of environment of conventional radiotherapy. The AB-BNCT system described in this study confirmed to specifications and is being used for BNCT in a hospital.


Power Burst Facility/Boron Neutron Capture Therapy Program for Cancer Treatment

Power Burst Facility/Boron Neutron Capture Therapy Program for Cancer Treatment
Author:
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Total Pages: 29
Release: 1990
Genre:
ISBN:

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This report discusses monthly progress in the Power Boron Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program for Cancer Treatment. Highlights of the PBF/BNCT Program during August 1990 include progress within the areas of: Gross Boron Analysis in Tissue, Blood, and Urine, boron microscopic (subcellular) analytical development, noninvasive boron quantitative determination, analytical radiation transport and interaction modeling for BNCT, large animal model studies, neutron source and facility preparation, administration and common support and PBF operations.


Boron Neutron Capture Therapy of Malignant Brain Tumors at the Brookhaven Medical Research Reactor

Boron Neutron Capture Therapy of Malignant Brain Tumors at the Brookhaven Medical Research Reactor
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Total Pages:
Release: 2001
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Boron neutron capture therapy (BNCT) is a bimodal form of radiation therapy for cancer. The first component of this treatment is the preferential localization of the stable isotope[sup 10]B in tumor cells by targeting with boronated compounds. The tumor and surrounding tissue is then irradiated with a neutron beam resulting in thermal neutron/[sup 10]B reactions ([sup 10]B(n, [alpha])[sup 7]Li) resulting in the production of localized high LET radiation from alpha and[sup 7]Li particles. These products of the neutron capture reaction are very damaging to cells, but of short range so that the majority of the ionizing energy released is microscopically confined to the vicinity of the boron-containing compound. In principal it should be possible with BNCT to selectively destroy small nests or even single cancer cells located within normal tissue. It follows that the major improvements in this form of radiation therapy are going to come largely from the development of boron compounds with greater tumor selectivity, although there will certainly be advances made in neutron beam quality as well as the possible development of alternative sources of neutron beams, particularly accelerator-based epithermal neutron beams.


Power Burst Facility

Power Burst Facility
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Total Pages: 27
Release: 1990
Genre:
ISBN:

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This report discusses the monthly progress of the Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNLT) program for cancer treatment. Highlights of the PBF/BNCT Program during July 1990 include progress within the areas of: Gross boron analysis in tissue, blood, and urine; noninvasive boron quantitative determination; analytical radiation transport and interaction modeling for BNCT; large animal model studies; neutron source and facility preparation; administration and common support and PBF operations.


Final Report for the "WSU Neutron Capture Therapy Facility Support."

Final Report for the
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Release: 2006
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ISBN:

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The objective for the cooperative research program for which this report has been written was to provide separate NCT facility user support for the students, faculty and scientists who would be doing the U.S. Department of Energy Office (DOE) of Science supported advanced radiotargeted research at the WSU 1 megawatt TRIGA reactor. The participants were the Idaho National laboratory (INL, P.I., Dave Nigg), the Veterinary Medical Research Center of Washington State University (WSU, Janean Fidel and Patrick Gavin), and the Washington State University Nuclear Radiation Center (WSU, P.I., Gerald Tripard). A significant number of DOE supported modifications were made to the WSU reactor in order to create an epithermal neutron beam while at the same time maintaining the other activities of the 1 MW reactor. These modifications were: (1) Removal of the old thermal column. (2) Construction and insertion of a new epithermal filter, collimator and shield. (3) Construction of a shielded room that could accommodate the very high radiation field created by an intense neutron beam. (4) Removal of the previous reactor core fuel cluster arrangement. (5) Design and loading of the new reactor core fuel cluster arrangement in order to optimize the neutron flux entering the epithermal neutron filter. (6) The integration of the shielded rooms interlocks and radiological controls into the SCRAM chain and operating electronics of the reactor. (7) Construction of a motorized mechanism for moving and remotely controlling the position of the entire reactor bridge. (8) The integration of the reactor bridge control electronics into the SCRAM chain and operating electronics of the reactor. (9) The design, construction and attachment to the support structure of the reactor of an irradiation box that could be inserted into position next to the face of the reactor. (Necessitated by the previously mentioned core rearrangement). All of the above modifications were successfully completed and tested. The resulting epithermal beam of 1 x 109 n/sec-cm2 was measured by Idaho National Laboratory with assistance from WSU's Neutron Activation Analysis Group. The beam is as good as our initial proposals for the project had predicted. In addition to all of the design, construction and insertion of the hardware, shielding, electronics and radiation monitoring systems there was considerable manpower and effort put into changes in the Technical Specifications of the reactor and implementing procedures for use of the new facility. This staff involvement is one of the reasons we requested special facility support from the DOE. Once the facility was competed and all of the recalibrations and measurements made to characterize the differences between this reactor core and the previous core we began to assist INL in making their beam measurements with foils and phantoms. Although we proposed support for only one additional staff position to support this new NCT facility the staff support provided by the WSU Nuclear Radiation Center was greater than had been anticipated by our initial proposal. INL was also assisted in the testing of a heavy water (deuterated water) bladder that can be inserted into the collimator in order to produce an intense, external thermal neutron beam. The external epithermal and/or thermal neutron beam capability remains available for use, if funding becomes available for future research projects.


Design of a New BNCT Facility Based on an ESQ Accelerator

Design of a New BNCT Facility Based on an ESQ Accelerator
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Total Pages: 8
Release: 1996
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ISBN:

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The authors plan to build a BNCT facility based on electrostatic quadrupole (ESQ) accelerator technology. It is an experimentally-proven technology capable of delivering a high proton current for producing a neutron intensity greater than what is required for BNCT clinical trials. They also present a design of a lithium neutron-production target with adequate cooling of the heat generated by the high-current proton beam.


A Small-Animal Irradiation Facility for Neutron Capture Therapy Research at the RA-3 Research Reactor

A Small-Animal Irradiation Facility for Neutron Capture Therapy Research at the RA-3 Research Reactor
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Release: 2007
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The National Atomic Energy Commission of Argentina (CNEA) has constructed a thermal neutron source for use in Boron Neutron Capture Therapy (BNCT) applications at the RA-3 research reactor facility located in Buenos Aires. The Idaho National Laboratory (INL) and CNEA have jointly conducted some initial neutronic characterization measurements for one particular configuration of this source. The RA-3 reactor (Figure 1) is an open pool type reactor, with 20% enriched uranium plate-type fuel and light water coolant. A graphite thermal column is situated on one side of the reactor as shown. A tunnel penetrating the graphite structure enables the insertion of samples while the reactor is in normal operation. Samples up to 14 cm height and 15 cm width are accommodated.


PET-based Approach to Treatment Planning Systems: An Improvement Towards Successful Boron Neutron Capture Therapy (BNCT). Essential for Energy and Health HFR High Flux Reactor & Reactor Applications

PET-based Approach to Treatment Planning Systems: An Improvement Towards Successful Boron Neutron Capture Therapy (BNCT). Essential for Energy and Health HFR High Flux Reactor & Reactor Applications
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Release: 2003
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