Controlled Human Inhalation Exposure Studies At Epa PDF Download
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Author | : National Academies of Sciences, Engineering, and Medicine |
Publisher | : National Academies Press |
Total Pages | : 159 |
Release | : 2017-05-10 |
Genre | : Science |
ISBN | : 030945249X |
Download Controlled Human Inhalation-Exposure Studies at EPA Book in PDF, ePub and Kindle
The U.S. Environmental Protection Agency (EPA) has a mission and regulatory responsibility to protect human health and the environment. EPA's pursuit of that goal includes a variety of research activities involving human subjects, such as epidemiologic studies and surveys. Those research activities also involve studies of individuals who volunteer to be exposed to air pollutants intentionally in controlled laboratory settings so that measurements can be made of transient and reversible biomarker or physiologic responses to those exposures that can indicate pathways of toxicity and mechanisms of air-pollution responses. The results of those controlled human inhalation exposure (CHIE) studies, also referred to as human clinical studies or human challenge studies, are used to inform policy decisions and help establish or revise standards to protect public health and improve air quality. Controlled Human Inhalation-Exposure Studies at EPA addresses scientific issues and provides guidance on the conduct of CHIE studies. This report assesses the utility of CHIE studies to inform and reduce uncertainties in setting air-pollution standards to protect public health and assess whether continuation of such studies is warranted. It also evaluates the potential health risks to test subjects who participated in recent studies of air pollutants at EPA's clinical research facility.
Author | : United States. Environmental Protection Agency. Office of Air and Radiation |
Publisher | : |
Total Pages | : 38 |
Release | : 1995 |
Genre | : Air quality |
ISBN | : |
Download The Inside Story Book in PDF, ePub and Kindle
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 187 |
Release | : 2010-03-18 |
Genre | : Nature |
ISBN | : 0309152356 |
Download Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene Book in PDF, ePub and Kindle
Tetrachloroethylene is a volatile, chlorinated organic hydrocarbon that is widely used as a solvent in the dry-cleaning and textile-processing industries and as an agent for degreasing metal parts. It is an environmental contaminant that has been detected in the air, groundwater, surface waters, and soil. In June 2008, the U.S. Environmental Protection Agency released its draft Toxicological Review of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS). The draft IRIS assessment provides quantitative estimates of cancer and noncancer effects of exposure to tetrachloreothylene, which will be used to establish airquality and water-quality standards to protect public health and to set cleanup standards for hazardous waste sites. At the request of EPA, the National Research Council conducted an independent scientific review of the draft IRIS assessment of tetrachloroethylene from toxicologic, epidemiologic, and human clinical perspectives. The resulting book evaluates the adequacy of the EPA assessment, the data and methods used for deriving the noncancer values for inhalation and oral exposures and the oral and inhalation cancer unit risks posed by tetrachloroethylene; evaluates whether the key studies underlying the draft IRIS assessment are of requisite quality, reliability, and relevance to support the derivation of the reference values and cancer risks; evaluates whether the uncertainties in EPA's risk assessment were adequately described and, where possible, quantified; and identifies research that could reduce the uncertainty in the current understanding of human health effects associated with tetrachloroethylene exposure.
Author | : |
Publisher | : DIANE Publishing |
Total Pages | : 525 |
Release | : 1996 |
Genre | : Air |
ISBN | : 1428904697 |
Download Review of the national ambient air quality standards for particulate matter policy assessment of scientific and technical information. Book in PDF, ePub and Kindle
Author | : |
Publisher | : DIANE Publishing |
Total Pages | : 72 |
Release | : |
Genre | : |
ISBN | : 1428904026 |
Download Human exposure assessment : a guide to risk ranking, risk reduction, and research planning Book in PDF, ePub and Kindle
Author | : National Center for Environmental Assessment (Research Triangle Park, N.C.) |
Publisher | : |
Total Pages | : 1100 |
Release | : 1996 |
Genre | : Air quality |
ISBN | : |
Download Air Quality Criteria for Particulate Matter Book in PDF, ePub and Kindle
Author | : United States. Environmental Protection Agency. Office of Water Regulations and Standards |
Publisher | : |
Total Pages | : 456 |
Release | : 1986 |
Genre | : Water |
ISBN | : |
Download Quality Criteria for Water, 1986 Book in PDF, ePub and Kindle
Section 304(a) (1) of the Clean Water Act 33 U.S.C. 1314(a) (1) requires the Environmental Protection Agency (EPA) to publish and periodically update ambient water quality criteria. These criteria are to accurately reflect the latest scientific knowledge (a) on the kind and extent of all identifiable effects on health and welfare including, but not limited to, plankton, fish shellfish, wildlife, plant life, shorelines, beaches, aesthetics, and recreation which may be expected from the presence of pollutants in any body of water including ground water; (b) on the concentration and dispersal of pollutants, or their byproducts, through biological, physical, and chemical processes; and (c) on the effects of pollutants on biological community diversity, productivity, and stability, including information on the factors affecting rates of eutrophication and organic and inorganic sedimentation for varying types of receiving waters. In a continuing effort to provide those who use EPA's water quality and human health criteria with up-to-date criteria values and associated information, the document was assembled. The document includes summaries of all the contaminants for which EPA has developed criteria recommendations.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 226 |
Release | : 2008-07-21 |
Genre | : Nature |
ISBN | : 0309177855 |
Download Estimating Mortality Risk Reduction and Economic Benefits from Controlling Ozone Air Pollution Book in PDF, ePub and Kindle
In light of recent evidence on the relationship of ozone to mortality and questions about its implications for benefit analysis, the Environmental Protection Agency asked the National Research Council to establish a committee of experts to evaluate independently the contributions of recent epidemiologic studies to understanding the size of the ozone-mortality effect in the context of benefit analysis. The committee was also asked to assess methods for estimating how much a reduction in short-term exposure to ozone would reduce premature deaths, to assess methods for estimating associated increases in life expectancy, and to assess methods for estimating the monetary value of the reduced risk of premature death and increased life expectancy in the context of health-benefits analysis. Estimating Mortality Risk Reduction and Economic Benefits from Controlling Ozone Air Pollution details the committee's findings and posits several recommendations to address these issues.
Author | : United States. National Air Pollution Control Administration |
Publisher | : |
Total Pages | : 188 |
Release | : 1970 |
Genre | : Air quality |
ISBN | : |
Download Air Quality Criteria for Carbon Monoxide Book in PDF, ePub and Kindle
Relationship between concentration of carbon monoxide in the air and its adverse effects on man and the environment.
Author | : |
Publisher | : |
Total Pages | : 414 |
Release | : 1997 |
Genre | : Health risk assessment |
ISBN | : |
Download Health Effects Assessment Summary Tables Book in PDF, ePub and Kindle