Conjugation And Deconjugation Of Ubiquitin Family Modifiers PDF Download
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Author | : |
Publisher | : |
Total Pages | : 274 |
Release | : 2011-08-01 |
Genre | : |
ISBN | : 9781441966773 |
Download Conjugation and Deconjugation of Ubiquitin Family Modifiers Book in PDF, ePub and Kindle
Author | : Marcus Groettrup |
Publisher | : Springer Science & Business Media |
Total Pages | : 270 |
Release | : 2011-01-11 |
Genre | : Science |
ISBN | : 1441966765 |
Download Conjugation and Deconjugation of Ubiquitin Family Modifiers Book in PDF, ePub and Kindle
† 1 a a 4 † 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUITINATION UBIQUITINATION 1 32 7 S) d 33 12 13 14 15 18 19 15 20 21 35 15 15 27 15 31 32 31 33 36 monoubiquitination of pol pol 34 37 34 monoubiquitination. 20 35 trans 3 15 REFERENCES by monoubiquitination. Mol Cell; 2009. UBIQUITIN LIGASE ACTIVITY BY Nedd 1 2 of 41 5 6 8 fold. 9 13 14 edd 43 18 18 K M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18
Author | : Michael Howard Tatham |
Publisher | : |
Total Pages | : 0 |
Release | : 2001 |
Genre | : |
ISBN | : |
Download Conjugation and Deconjugation of the Small Ubiquitin-like Modifiers SUMO-1, SUMO-2 and SUMO-3 Book in PDF, ePub and Kindle
Author | : R. Jürgen Dohmen |
Publisher | : Humana Press |
Total Pages | : 666 |
Release | : 2016-08-23 |
Genre | : Science |
ISBN | : 9781493959051 |
Download Ubiquitin Family Modifiers and the Proteasome Book in PDF, ePub and Kindle
The ubiquitin-proteasome system (UPS) and ubiquitin-related modifiers are not only involved in cellular protein quality control but also in the regulation of many fundamental cellular processes/pathways as well as in their disease-relevant aberrations. Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols presents both novel developments in UPS research and important methods related to the main recent advances in the field of ubiquitin family modifiers. Divided into five convenient sections, this volume focuses on the enzymology and substrate identification of ubiquitin family modifiers, the recognition and chain formation of these modifiers, the analysis of proteasome biogenesis and function, protein quality control, and finally the use of small molecules and strategies to study or manipulate the function of the UPS and of ubiquitin family modifiers, respectively. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols will be of great use to investigators and students engaged in both basic and applied research in life sciences.
Author | : Robert M. Brosh Jr. |
Publisher | : MDPI |
Total Pages | : 368 |
Release | : 2019-08-27 |
Genre | : Science |
ISBN | : 303921389X |
Download DNA Replication Stress Book in PDF, ePub and Kindle
This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS
Author | : |
Publisher | : Academic Press |
Total Pages | : 308 |
Release | : 2019-02-01 |
Genre | : Science |
ISBN | : 0128167041 |
Download International Review of Cell and Molecular Biology Book in PDF, ePub and Kindle
International Review of Cell and Molecular Biology, Volume 343 reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. Sections in this new release include The Molecular and Cellular Regulation of Brassicaceae Self-Incompatibility and Self-Pollen Rejection, Regulation of Plant Immunity by the Proteasome, the Role of the Ubiquitin Proteasome System in Plant Response to Abiotic Stress, Glycosylation in Anticancer Immunity, Emerging Themes in PDZ Domain Signaling: Structure, Function and Inhibition, and more. Publishes invited review articles on selected topics as authored by established and active cell and molecular biologists whose work is drawn from international sources Offers a wide range of perspectives on specific subjects
Author | : Rosa Barrio |
Publisher | : Springer Nature |
Total Pages | : 350 |
Release | : 2020-04-09 |
Genre | : Science |
ISBN | : 3030382664 |
Download Proteostasis and Disease Book in PDF, ePub and Kindle
This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Author | : Yi Sun |
Publisher | : Springer Nature |
Total Pages | : 372 |
Release | : 2020-01-02 |
Genre | : Science |
ISBN | : 9811510253 |
Download Cullin-RING Ligases and Protein Neddylation Book in PDF, ePub and Kindle
This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.
Author | : Michael Breitenbach |
Publisher | : Springer Science & Business Media |
Total Pages | : 373 |
Release | : 2011-11-19 |
Genre | : Science |
ISBN | : 9400725612 |
Download Aging Research in Yeast Book in PDF, ePub and Kindle
This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.
Author | : Xiaoyuan Wang |
Publisher | : Springer Science & Business Media |
Total Pages | : 445 |
Release | : 2012-10-20 |
Genre | : Computers |
ISBN | : 9400750544 |
Download Reprogramming Microbial Metabolic Pathways Book in PDF, ePub and Kindle
Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production. This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.