Computational Modeling Of Membrane Bilayers PDF Download
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Author | : V. Sundararajan |
Publisher | : Academic Press |
Total Pages | : 493 |
Release | : 2011-08-29 |
Genre | : Science |
ISBN | : 0080920500 |
Download Computational Modeling of Membrane Bilayers Book in PDF, ePub and Kindle
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. Discusses the current state of electrostatics in biomolecular simulations and future directions Includes information on time and length scales in lipid bilayer simulations Includes a chapter on the nature of lipid rafts
Author | : Scott E. Feller |
Publisher | : |
Total Pages | : 466 |
Release | : 2008 |
Genre | : Bilayer lipid membranes |
ISBN | : |
Download Current Topics in Membranes Book in PDF, ePub and Kindle
Author | : Max L. Berkowitz |
Publisher | : CRC Press |
Total Pages | : 258 |
Release | : 2019-04-30 |
Genre | : Science |
ISBN | : 1351060309 |
Download Biomembrane Simulations Book in PDF, ePub and Kindle
Due to recent advancements in the development of numerical algorithms and computational hardware, computer simulations of biological membranes, often requiring use of substantial computational resources, are now reaching a mature stage. Since molecular processes in membranes occur on a multitude of spatial and time scales, molecular simulations of membranes can also serve as a testing ground for use of multi-scale simulation techniques. This book addresses some of the important issues related to understanding properties and behavior of model biological membranes and it Shows how simulations improve our understanding of biological membranes and makes connections with experimental results. Presents a careful discussion of the force fields used in the membrane simulations including detailed all-atom fields and coarse-grained fields. Presents a continuum description of membranes. Discusses a variety of issues such as influence of membrane surfaces on properties of water, interaction between membranes across water, nanoparticle permeation across the membrane, action of anesthetics and creation of inhomogeneous regions in membranes. Discusses important methodological issues when using simulations to examine phenomena such as pore creation and permeation across membranes. Discusses progress recently achieved in modeling bacterial membranes. It will be a valuable resource for graduate students, researchers and instructors in biochemistry, biophysics, pharmacology, physiology, and computational biology.
Author | : Max L. Berkowitz |
Publisher | : CRC Press |
Total Pages | : 334 |
Release | : 2019-04-30 |
Genre | : Science |
ISBN | : 1351060295 |
Download Biomembrane Simulations Book in PDF, ePub and Kindle
Due to recent advancements in the development of numerical algorithms and computational hardware, computer simulations of biological membranes, often requiring use of substantial computational resources, are now reaching a mature stage. Since molecular processes in membranes occur on a multitude of spatial and time scales, molecular simulations of membranes can also serve as a testing ground for use of multi-scale simulation techniques. This book addresses some of the important issues related to understanding properties and behavior of model biological membranes and it Shows how simulations improve our understanding of biological membranes and makes connections with experimental results. Presents a careful discussion of the force fields used in the membrane simulations including detailed all-atom fields and coarse-grained fields. Presents a continuum description of membranes. Discusses a variety of issues such as influence of membrane surfaces on properties of water, interaction between membranes across water, nanoparticle permeation across the membrane, action of anesthetics and creation of inhomogeneous regions in membranes. Discusses important methodological issues when using simulations to examine phenomena such as pore creation and permeation across membranes. Discusses progress recently achieved in modeling bacterial membranes. It will be a valuable resource for graduate students, researchers and instructors in biochemistry, biophysics, pharmacology, physiology, and computational biology.
Author | : Chun-Liang Lai |
Publisher | : |
Total Pages | : 168 |
Release | : 2013 |
Genre | : |
ISBN | : 9781303228896 |
Download Computational Modeling of Biomolecular Systems: Molecular Mechanism of Membrane Binding of Peripheral Membrane Proteins Book in PDF, ePub and Kindle
Peripheral membrane targeting proteins play essential roles in numerous cellular trafficking and signaling pathways. At the molecular level, the interactions between lipids and protein side chains at the binding interfaces drive the membrane targeting. High-resolution techniques to describe the structure and dynamics of protein-membrane complex are valuable, however, detailed mechanistic analysis of membrane targeting events remains a great challenge. Molecular dynamics (MD) simulations have proven to be a useful tool in revealing molecular-level details at the binding interfaces. This thesis will describe the use of MD simulations, in some cases with experimental inputs, to investigate molecular membrane binding mechanisms for three biologically relevant peripheral membrane protein systems, including epsin N-terminal homology (ENTH), general receptor for phosphoinositides 1 (GRP1) PH, protein kinase C alpha (PKCalpha) C2 domains.
Author | : Benoit Roux |
Publisher | : World Scientific |
Total Pages | : 209 |
Release | : 2021-08-23 |
Genre | : Computers |
ISBN | : 9811232776 |
Download Computational Modeling And Simulations Of Biomolecular Systems Book in PDF, ePub and Kindle
This textbook originated from the course 'Simulation, Modeling, and Computations in Biophysics' that I have taught at the University of Chicago since 2011. The students typically came from a wide range of backgrounds, including biology, physics, chemistry, biochemistry, and mathematics, and the course was intentionally adapted for senior undergraduate students and graduate students. This is not a highly technical book dedicated to specialists. The objective is to provide a broad survey from the physical description of a complex molecular system at the most fundamental level, to the type of phenomenological models commonly used to represent the function of large biological macromolecular machines.The key conceptual elements serving as building blocks in the formulation of different levels of approximations are introduced along the way, aiming to clarify as much as possible how they are interrelated. The only assumption is a basic familiarity with simple mathematics (calculus and integrals, ordinary differential equations, matrix linear algebra, and Fourier-Laplace transforms).
Author | : Carmen Domene |
Publisher | : Royal Society of Chemistry |
Total Pages | : 275 |
Release | : 2016-11-30 |
Genre | : Science |
ISBN | : 1782626697 |
Download Computational Biophysics of Membrane Proteins Book in PDF, ePub and Kindle
Exploring current themes in modern computational and membrane protein biophysics, this book presents a comprehensive account of the fundamental principles underlying different methods and techniques used to describe the intriguing mechanisms by which membrane proteins function. The book discusses the experimental approaches employed to study these proteins, with chapters reviewing recent crucial structural advances that have allowed computational biophysicists to discern how these molecular machines work. The book then explores what computational methods are available to researchers and what these have taught us about three key families of membrane proteins: ion channels, transporters and receptors. The book is ideal for researchers in computational chemistry and computational biophysics.
Author | : Erik Lindahl |
Publisher | : |
Total Pages | : 74 |
Release | : 2001 |
Genre | : |
ISBN | : 9789172830882 |
Download Computational Modeling of Biological Membrane and Interface Dynamics Book in PDF, ePub and Kindle
Author | : Georg Pabst |
Publisher | : CRC Press |
Total Pages | : 482 |
Release | : 2014-03-04 |
Genre | : Medical |
ISBN | : 1466507098 |
Download Liposomes, Lipid Bilayers and Model Membranes Book in PDF, ePub and Kindle
As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evolved from basic studies of the physicochemical properties of amphiphiles to their application in industry and medicine. Written by leading researchers in their fields, this book describes basic and applied research, and serves as a useful reference for both the novice and the expert. Part one covers a range of basic research topics, from theory and computational simulations to some of the most up-to-date experimental research. Topics discussed include soft matter physics of membranes, nonlamellar phases, extraction of molecules by amphiphiles, lipid models for membrane rafts, membrane dynamics, nanodiscs, microemulsions, active membranes, as well as interactions of bilayers with drugs or DNA to treat disease or for gene transfer, respectively. Part two of the book focuses on technological applications of amphiphiles, such as liposome-based nanoparticles for drug delivery, formulation of liposomes for prolonged in vivo circulation and functionalization for medical purposes, novel drug delivery systems for increased drug loading, and the use of tethered membranes for bio-sensing applications. Chapters also describe the use of liposomes in textile dyeing and how lipidic nanoparticles are used by the food industry.
Author | : David J. Steigmann |
Publisher | : Springer |
Total Pages | : 338 |
Release | : 2017-05-23 |
Genre | : Science |
ISBN | : 3319563483 |
Download The Role of Mechanics in the Study of Lipid Bilayers Book in PDF, ePub and Kindle
This book is the first collection of lipid-membrane research conducted by leading mechanicians and experts in continuum mechanics. It brings the overall intellectual framework afforded by modern continuum mechanics to bear on a host of challenging problems in lipid membrane physics. These include unique and authoritative treatments of differential geometry, shape elasticity, surface flow and diffusion, interleaf membrane friction, phase transitions, electroelasticity and flexoelectricity, and computational modelling.