Complex Enzymes In Microbial Natural Product Biosynthesis Part A Overview Articles And Peptides PDF Download
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Author | : |
Publisher | : Academic Press |
Total Pages | : 703 |
Release | : 2009-04-10 |
Genre | : Medical |
ISBN | : 0080923356 |
Download Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides Book in PDF, ePub and Kindle
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. Gathers tried and tested methods and techniques from top players in the field In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides Provides an extremely useful reference for the experienced research scientist
Author | : |
Publisher | : Academic Press |
Total Pages | : 350 |
Release | : 2009-05-08 |
Genre | : Science |
ISBN | : 9780123745880 |
Download Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides Book in PDF, ePub and Kindle
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. * Gathers tried and tested methods and techniques from top players in the field. * In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides. * Provides an extremely useful reference for the experienced research scientist.
Author | : |
Publisher | : Academic Press |
Total Pages | : 644 |
Release | : 2009-04-11 |
Genre | : Science |
ISBN | : 0080923364 |
Download Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates Book in PDF, ePub and Kindle
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. Gathers tried and tested methods and techniques from top players in the field Provides an extremely useful reference for the experienced research scientist Covers biosynthesis of Polyketides, Tarpenoids, Aminocoumarins and Crabohydrates
Author | : D. A. Hopwood |
Publisher | : |
Total Pages | : 581 |
Release | : 2009 |
Genre | : Biosynthesis |
ISBN | : 9780123745910 |
Download Complex Enzymes in Microbial Natural Product Biosynthesis Book in PDF, ePub and Kindle
Author | : |
Publisher | : Academic Press |
Total Pages | : 350 |
Release | : 2009-05-08 |
Genre | : Science |
ISBN | : 9780123745880 |
Download Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides Book in PDF, ePub and Kindle
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. * Gathers tried and tested methods and techniques from top players in the field. * In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides. * Provides an extremely useful reference for the experienced research scientist.
Author | : |
Publisher | : Academic Press |
Total Pages | : 0 |
Release | : 2009-04-24 |
Genre | : Science |
ISBN | : 9780123745910 |
Download Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates Book in PDF, ePub and Kindle
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine.
Author | : D. A. Hopwood |
Publisher | : |
Total Pages | : 0 |
Release | : 2009 |
Genre | : Biosynthesis |
ISBN | : |
Download Complex Enzymes in Microbial Natural Product Biosynthesis Book in PDF, ePub and Kindle
Author | : D. A. Hopwood |
Publisher | : Academic Press |
Total Pages | : 464 |
Release | : 2012 |
Genre | : Alkaloids |
ISBN | : 0123942918 |
Download Natural Product Biosynthesis by Microorganisms and Plants Book in PDF, ePub and Kindle
Annotation This volume of 'Methods in Enzymology' continues the legacy of this premier serial by containing quality chapters authored by leaders in the field.
Author | : Zhiyong Li |
Publisher | : Springer |
Total Pages | : 570 |
Release | : 2019-06-07 |
Genre | : Science |
ISBN | : 9402416129 |
Download Symbiotic Microbiomes of Coral Reefs Sponges and Corals Book in PDF, ePub and Kindle
This book focuses on the symbiotic microbiomes of invertebrates in coral reefs, especially sponges and corals. It provides in-depth and up-to-date reviews on the microbial structure and diversity, metabolism and function, symbiosis and coevolution, environment and adaption, and bioactive potentials. Meanwhile, the future perspectives will be discussed according to the existing problems and the development trend. This book will be of particular interest to the professionals in marine ecology, marine biotechnology, as well as medicinal chemists and molecular biologists.
Author | : |
Publisher | : Elsevier |
Total Pages | : 474 |
Release | : 2016-07-29 |
Genre | : Science |
ISBN | : 0128111232 |
Download Synthetic Biology and Metabolic Engineering in Plants and Microbes Part B: Metabolism in Plants Book in PDF, ePub and Kindle
Synthetic Biology and Metabolic Engineering in Plants and Microbes, Part B, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods, synthetic biology, and metabolic engineering in plants and microbes, and includes sections on such topics as the usage of integrases in microbial engineering, biosynthesis, and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways. Continues the legacy of this premier serial with quality chapters authored by leaders in the field of enzymology Contains two volumes covering research methods in synthetic biology and metabolic engineering in plants and microbes Includes sections on such topics as the uses of integrases in microbial engineering, biosynthesis and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways