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Coalescent

Coalescent
Author: Stephen Baxter
Publisher: Del Rey
Total Pages: 546
Release: 2004-11-23
Genre: Fiction
ISBN: 0345457862
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“Lean, taut storytelling . . . breakneck stuff . . . Arguably his most accessible book to date—Baxter [is] resplendent.”—SFX magazine When his father dies suddenly, George Poole stumbles onto a family secret: He has a twin sister he never knew existed, who was raised by an enigmatic cult called the Order. The Order is a hive—a human hive with a dominant queen—that has prospered below the streets of Rome for almost two millennia. After Poole enters the Order’s vast underground city and meets the disturbing inhabitants, he uncovers evidence that they have embarked on a divergent evolutionary path. These genetically superior humans are equipped with the tools necessary to render modern Homo sapiens as extinct as the Neanderthals. And now they are preparing to leave their underground realm. “[Excels] at both action-packed storytelling and philosophical speculation.”—Library Journal “Utterly fascinating . . . constantly surprising . . . Coalescent reveals a new side to Baxter’s vast talent.”—Locus

Coalescent Theory

Coalescent Theory
Author: John Wakely
Publisher: Roberts
Total Pages: 0
Release: 2016-04-22
Genre: Science
ISBN: 9780974707754
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This textbook provides the foundation for molecular population genetics and genomics. It shows the conceptual framework for studies of DNA sequence variation within species, and is the source of essential tools for making inferences about mutation, recombination, population structure and natural selection from DNA sequence data.

Coalescent Argumentation

Coalescent Argumentation
Author: Michael A. Gilbert
Publisher: Routledge
Total Pages: 172
Release: 2013-11-05
Genre: Language Arts & Disciplines
ISBN: 1136685243
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Coalescent Argumentation is based on the concept that arguments can function from agreement, rather than disagreement. To prove this idea, Gilbert first discusses how several components--emotional, visceral (physical) and kisceral (intuitive) are utilized in an argumentative setting by people everyday. These components, also characterized as "modes," are vital to argumentative communication because they affect both the argument and the resulting outcome. In addition to the components/modes, this book also stresses the goals in argumentation as a means for understanding one's own and one's opposer's positions. Gilbert argues that by viewing positions as complex human events involving a variety of communicative modes, we are better able to find commonalities across positions, and, therefore, move from conflict to resolution. By focusing on agreement and shared goals in all modes, arguers can coalesce diverse positions and more easily distinguish between minor or unrelated differences and core disagreements. This permits much greater latitude for locating shared beliefs, values, and attitudes that will lead to conflict resolution.

Handbook of Statistical Genomics

Handbook of Statistical Genomics
Author: David J. Balding
Publisher: John Wiley & Sons
Total Pages: 1828
Release: 2019-07-09
Genre: Science
ISBN: 1119429250
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A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

Gene Genealogies, Variation and Evolution: A primer in coalescent theory

Gene Genealogies, Variation and Evolution: A primer in coalescent theory
Author: Jotun Hein
Publisher: Oxford University Press, USA
Total Pages: 298
Release: 2004-12-09
Genre: Population genetics
ISBN: 9780191546150
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Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. - Professor Montgomery Slatkin (Berkeley);the authors are outstanding experts in the field, and the book is topical and timely. - Professor David Balding (Imperial College);Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. - Professor Joe Felsenstein (University of Washington)

Exultant

Exultant
Author: Stephen Baxter
Publisher: Del Rey
Total Pages: 482
Release: 2004-10-26
Genre: Fiction
ISBN: 0345457900
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“Baxter has an uncanny gift for mixing a punchy, cyberpunk cynicism with his resolutely hard SF story base. . . . [Exultant] rivals Asimov in its boundless vision for the future evolution of humanity.”—Kirkus Reviews (starred review) For more than twenty thousand years, humans have been at war with the alien race of Xeelee. Faced with certain death, a young pilot, Pirius, disobeys orders and travels into the future. Upon his return, Pirius is court-martialed and sentenced to penal servitude. But it is not only Pirius who pays the price. In flying into the future and back again, Pirius returned to a time before he’d left, a time inhabited by his younger self, who also receives punishment. Commissary Nilis believes that the elder Pirius, whom he dubs Pirius Blue, may know how to defeat the Xeelee. But Nilis can do nothing for Pirius Blue. Instead, he takes the younger Pirius—Pirius Red—back to Earth. There Pirius Red will discover truths that shatter his preconceived notions of all that he is fighting for, while Pirius Blue will learn even harsher truths. But the most shocking revelation of all is still to come. “Absurdly ambitious, technically brilliant, and downright exciting.”—SFX Magazine “Striking . . . chilling . . . [with] a triumphant conclusion.”—Starburst

Statistical Population Genomics

Statistical Population Genomics
Author: Julien Y Dutheil
Publisher:
Total Pages: 464
Release: 2020-10-08
Genre: Science
ISBN: 9781013271403
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This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including demography inference, population structure analysis and detection of selection, using both model-based inference and simulation procedures. Last but not least, it offers an overview of the current knowledge acquired by applying such methods to a large variety of eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, pointers to the relevant literature, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Statistical Population Genomics aims to promote and ensure successful applications of population genomic methods to an increasing number of model systems and biological questions. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Harmony of Gr”bner Bases and the Modern Industrial Society

Harmony of Gr”bner Bases and the Modern Industrial Society
Author: Takayuki Hibi
Publisher: World Scientific
Total Pages: 385
Release: 2012
Genre: Mathematics
ISBN: 9814383465
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This volume consists of research papers and expository survey articles presented by the invited speakers of the conference on OC Harmony of GrAbner Bases and the Modern Industrial SocietyOCO. Topics include computational commutative algebra, algebraic statistics, algorithms of D-modules and combinatorics. This volume also provides current trends on GrAbner bases and will stimulate further development of many research areas surrounding GrAbner bases."

Transcendent

Transcendent
Author: Stephen Baxter
Publisher: Del Rey
Total Pages: 558
Release: 2005-11-29
Genre: Fiction
ISBN: 0345457935
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“Breathtaking . . . brilliantly conducted . . . Far-future philosophic space opera and near-future eco-thriller combine effectively.”—Locus It is the year 2047, and nuclear engineer Michael Poole is mourning the death of his beloved wife and doubting his own sanity. But he must stave off a looming catastrophe: vast reservoirs of toxic gases lie beneath the melting poles, threatening to contaminate the atmosphere and destroy all life on Earth. Though born five hundred thousand years after the death of Michael Poole, Alia knows him intimately. Every person in Alia’s world is entrusted with Witnessing one life from the past by means of a technology able to traverse time. Alia’s subject is Michael Poole. Chosen to become a Transcendent, a member of the group mind that is shepherding humanity toward an evolutionary apotheosis, Alia discovers a dark side to the Transcendent’s plans. Somehow, Michael holds the fate of the future in his hands, and to save that future, Alia must undertake a desperate journey into the past. “Stunning . . . engaging . . . a contrasting mix of Baxter’s customary skill at presenting a very realnear future, and his talent for high-level hardscience fiction.”—Starburst

Population Genetics

Population Genetics
Author: Matthew B. Hamilton
Publisher: John Wiley & Sons
Total Pages: 501
Release: 2021-02-10
Genre: Science
ISBN: 111843689X
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Now updated for its second edition, Population Genetics is the classic, accessible introduction to the concepts of population genetics. Combining traditional conceptual approaches with classical hypotheses and debates, the book equips students to understand a wide array of empirical studies that are based on the first principles of population genetics. Featuring a highly accessible introduction to coalescent theory, as well as covering the major conceptual advances in population genetics of the last two decades, the second edition now also includes end of chapter problem sets and revised coverage of recombination in the coalescent model, metapopulation extinction and recolonization, and the fixation index.