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Challenges of Biological Aging

Challenges of Biological Aging
Author: Edward J. Masoro
Publisher: Springer Publishing Company
Total Pages: 218
Release: 2000-09-05
Genre: Science
ISBN: 0826100821

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This volume provides the non-biologist an overview of what is known about the physiological bases of aging. The author examines the many basic theories and emerging hypotheses underlying the molecular, cellular, and systemic processes involved in senescence. He addresses the normal physiological changes that characterize the aging phenotype, and also considers the role of many age-associated diseases in growing older. Masoro synthesizes a much-needed "unified theory" of biological aging to which explains how and why the body grows into the condition we call "old." This text is intended for gerontology students in training, as well as for human physiologists interested in gerontology.


Problems of Ageing

Problems of Ageing
Author: Edmund Vincent Cowdry
Publisher:
Total Pages: 1100
Release: 1952
Genre: Age
ISBN:

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The Challenge

The Challenge
Author: Charles H. Barrows
Publisher:
Total Pages: 11
Release: 1971
Genre: Aging
ISBN:

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Epigenetics of Aging

Epigenetics of Aging
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
Total Pages: 462
Release: 2009-11-11
Genre: Medical
ISBN: 1441906398

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Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.


Problems of Ageing

Problems of Ageing
Author: Edmund Vincent Cowdry
Publisher:
Total Pages: 808
Release: 1979
Genre: Family & Relationships
ISBN:

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New Directions in the Sociology of Aging

New Directions in the Sociology of Aging
Author: Panel on New Directions in Social Demography, Social Epidemiology, and the Sociology of Aging
Publisher: National Academies Press
Total Pages: 301
Release: 2014-01-09
Genre: Social Science
ISBN: 9780309292979

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The aging of the population of the United States is occurring at a time of major economic and social changes. These economic changes include consideration of increases in the age of eligibility for Social Security and Medicare and possible changes in benefit levels. Furthermore, changes in the social context in which older individuals and families function may well affect the nature of key social relationships and institutions that define the environment for older persons. Sociology offers a knowledge base, a number of useful analytic approaches and tools, and unique theoretical perspectives that can facilitate understanding of these demographic, economic, and social changes and, to the extent possible, their causes, consequences and implications. The Future of the Sociology of Aging: An Agenda for Action evaluates the recent contributions of social demography, social epidemiology and sociology to the study of aging and identifies promising new research directions in these sub-fields. Included in this study are nine papers prepared by experts in sociology, demography, social genomics, public health, and other fields, that highlight the broad array of tools and perspectives that can provide the basis for further advancing the understanding of aging processes in ways that can inform policy. This report discusses the role of sociology in what is a wide-ranging and diverse field of study; a proposed three-dimensional conceptual model for studying social processes in aging over the life cycle; a review of existing databases, data needs and opportunities, primarily in the area of measurement of interhousehold and intergenerational transmission of resources, biomarkers and biosocial interactions; and a summary of roadblocks and bridges to transdisciplinary research that will affect the future directions of the field of sociology of aging.


The Biology of Ageing

The Biology of Ageing
Author: Gurcharan Rai
Publisher: CRC Press
Total Pages: 355
Release: 2022-02-16
Genre: Medical
ISBN: 1000605191

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One of the problems geriatricians are confronted with in everyday clinical practice is differentiating disease from the process of old age. The challenges of ageing require a better understanding of the essential biology of ageing in order to separate ageing from disease, and indeed ageing made worse by disease. Although the topic is large and diverse, this practical and easy-to-read reference book contains vital information on the biology of ageing. It provides a concise understanding of the changes that occur and focuses on the clinical implications of ageing. MCQs are featured throughout for revision and examination practice. The Biology of Ageing provides the reader with: . a learning guide on the biology of ageing through an overview of the changes that occur at both cellular and system levels . knowledge of how biological changes of ageing impact on physiology and the clinical relevance in medical practice . a practical consideration of these changes in disease presentations and how these changes may impact on disease management. This full-colour guide featuring slides, MRIs, figures and photographs is ideal for doctors training in geriatric medicine, practising geriatricians and those with an interest in management of older people.


Health, Illness, and Optimal Aging

Health, Illness, and Optimal Aging
Author: Carolyn M. Aldwin
Publisher: SAGE Publications
Total Pages: 441
Release: 2003-07-17
Genre: Social Science
ISBN: 1452266980

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FROM THE FOREWORD by James Birren: "Gaining understanding of aging is one of the most complex issues facing twenty-first century science. This book addresses the complexity of the factors that interact and influence the course of our longer life expectancy....How we humans grow old is a product of our genetic background as members of a species and our families. But the genome expresses itself in physical and social environments that modulate the appearance of heredity traits. In a sense aging is an ecological problem in which the dynamics are often difficult to explain....This book brings information from the sciences together in a way that is rarely done.....It provides an integration of knowledge about the dynamics of aging and can promote wisdom about how we can modify the life course to our advantage." In Health, Illness, and Optimal Aging: Biological and Psychosocial Perspectives, Carolyn M. Aldwin and Diane F. Gilmer undertake the challenging task of assembling an objective and holistic picture of human aging. The authors provide comprehensive, multidisciplinary coverage of the physical aspects of aging, including age-related changes and disease-related processes, the demography of the aging population, theories of aging, and the promotion of optimal aging. In addition, the book covers the psychosocial aspects of aging, including mental health, stress and coping, spirituality, and care giving in later years. Features of this book: Integrated. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Comprehensive. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Pedagogical. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data.Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Health, Illness and Optimal Aging is recommended for researchers seeking an overview of health psychology and aging, as well as undergraduate and graduate students taking classes in the social, behavioral, and health sciences. This text is also valuable for practitioners working with the elderly in fields such as nursing, social work, occupational and physical therapy, day-care and nursing home administration, psychology, and rehabilitation.


The Biology of Senescence

The Biology of Senescence
Author: Alex Comfort
Publisher: CreateSpace
Total Pages: 274
Release: 2010-11-25
Genre:
ISBN: 9781456392420

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The Biology of Senescence


Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Biochemistry and Cell Biology of Ageing: Part II Clinical Science
Author: J. Robin Harris
Publisher: Springer
Total Pages: 499
Release: 2019-03-19
Genre: Medical
ISBN: 9811336814

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This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.