Cancer Metastasis and Cancer Stem Cell/Niche
Author | : Takanori Kawaguchi |
Publisher | : Bentham Science Publishers |
Total Pages | : 157 |
Release | : 2016-11-04 |
Genre | : Medical |
ISBN | : 1681083477 |
Download Cancer Metastasis and Cancer Stem Cell/Niche Book in PDF, ePub and Kindle
A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches. Cancer Metastasis and Stem Cell/Niche explains the invasiveness and metastasis of cancer cells I the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs, their niche and metastasis, the regulation of cell surface glycan expression in CSCs, tumor endothelial cells and metastasis, toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment, and in surgical cancer metastasis. This monograph is intended as a primary reference on CSC research for physiologists, clinical oncologists, stem cell researchers and molecular biologists.