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On the Cancer Frontier

On the Cancer Frontier
Author: Paul Marks
Publisher: PublicAffairs
Total Pages: 274
Release: 2014-03-11
Genre: Medical
ISBN: 1610392531

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In 1950, a diagnosis of cancer was all but a death sentence. Mortality rates only got worse, and as late as 1986, an article in the New England Journal of Medicine lamented: "We are losing the war against cancer." Cancer is one of humankind's oldest and most persistent enemies; it has been called the existential disease. But we are now entering a new, and more positive, phase in this long campaign. While cancer has not been cured -- and a cure may elude us for a long time yet -- there has been a revolution in our understanding of its nature. Years of brilliant science have revealed how this individualistic disease seizes control of the foundations of life -- our genes -- and produces guerrilla cells that can attack and elude treatments. Armed with those insights, scientists have been developing more effective weapons and producing better outcomes for patients. Paul A. Marks, MD, has been a leader in these efforts to finally control this devastating disease. Marks helped establish the strategy for the "war on cancer" in 1971 as a researcher and member of President Nixon's cancer panel. As the president and chief executive officer for nineteen years at the world's pre-eminent cancer hospital, the Memorial Sloan-Kettering Cancer Center, he was instrumental in ending the years of futility. He also developed better therapies that promise a new era of cancer containment. Some cancers, like childhood leukemia and non-Hodgkin's lymphoma, that were once deadly conditions, are now survivable -- even curable. New steps in prevention and early diagnosis are giving patients even more hope. On the Cancer Frontier is Marks' account of the transformation in our understanding of cancer and why there is growing optimism in our ability to stop it.


On the Cancer Frontier

On the Cancer Frontier
Author: Paul Marks
Publisher: Public Affairs
Total Pages: 274
Release: 2014-03-11
Genre: Medical
ISBN: 1610392523

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Describes how and what doctors have learned about cancer and the mechanisms of the rogue, abnormal cells since the 1950s and catalogs the advances and strides made in treating and fighting the disease in the last half-century.


Frontiers in Oncology: Quarterly Highlights. Quarter 1 2019

Frontiers in Oncology: Quarterly Highlights. Quarter 1 2019
Author: Giuseppe Giaccone
Publisher: Frontiers Media SA
Total Pages: 213
Release: 2019-07-01
Genre:
ISBN: 288945939X

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Foreword from the Field Chief Editor, Giuseppe Giaccone Once again Frontiers in Oncology has started the year on a positive note, breaking previous records for submissions and publications, as well as the number of Research Topic article collections posted. The journal continues to grow in size, adding an 18th section focusing on Cancer Metabolism, led by Michael Lisanti and Ubaldo Martinez-Outschoorn, and has brought on a total of five new Chief Editors. Here, introducing Frontiers in Oncology: Quarterly Highlights, we feature a collection of carefully selected articles published during the first quarter of 2019 across the different sections. With a record number of papers to choose from, the papers enclosed in this Special Edition highlight some of the recent advances across the different disciplines. With an array of papers looking at everything from translational research to association studies and clinical trial results, Frontiers in Oncology continues to publish high-quality research from researchers around the world. Many of the recently posted Research Topics in the journal focus on early diagnosis and prevention, as well as the importance of survivorship studies and outcomes of cancer treatment. Consideration of such aspects of cancer research and treatment is pivotal in the global effort towards increased survival rates and improved quality of life. With ASCO 2019 marking the end of Q1 and the transition into Q2, the journal looks forward to the rest of the year, and continuing to play an active role in the research community. Giuseppe Giaccone


Cancer Frontier

Cancer Frontier
Author: 桑野信彦
Publisher:
Total Pages: 0
Release: 2002-11-15
Genre: Literary Collections
ISBN: 9784753220052

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Frontiers in Oncology World Cancer Day 2019 Special Edition

Frontiers in Oncology World Cancer Day 2019 Special Edition
Author: Giuseppe Giaccone
Publisher: Frontiers Media SA
Total Pages: 233
Release: 2019-02-04
Genre:
ISBN: 2889457818

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Advances in cancer research over the recent decades have been plentiful and often successful, with 5 year survival rates increasing almost uniformly across the board. The advent of new technologies has presented solutions for yesterday’s barriers to research, allowing us to leap forward in our ability to prevent, diagnose, and treat various cancers. Developments in omics studies has provided new insights into the underlying molecular basis of different cancers and their subtypes, greatly enhancing our understanding of the vast heterogeneity that exists. Progress in our ability to diagnose and detect early-stage cancers has resulted in numerous screening and prevention programs. Novel imaging technologies allow us to study and comprehend cancers with greater clarity than ever before. Although the field, as a whole, has experienced many successes, arduous challenges must be overcome in order to see continued success. The truth of the matter is cancer related deaths continue to rise in number worldwide, especially in lower- and middle-income countries. It is evident that there is still a lot of work to be done. This Frontiers in Oncology Special Issue marks the 1st edition of a collection of selected articles published in the journal over the course of the previous calendar year, highlighting ongoing research and advances being carried out in the different disciplines of cancer research.


Re-Irradiation: New Frontiers

Re-Irradiation: New Frontiers
Author: Carsten Nieder
Publisher: Springer
Total Pages: 368
Release: 2016-10-25
Genre: Medical
ISBN: 3319418254

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This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.


Frontiers in Radiation Oncology

Frontiers in Radiation Oncology
Author: Tejinder Kataria
Publisher: BoD – Books on Demand
Total Pages: 230
Release: 2013-07-03
Genre: Science
ISBN: 9535111639

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The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research.


Frontier Cancer Medicine Guide

Frontier Cancer Medicine Guide
Author: Karol Sikora
Publisher:
Total Pages: 96
Release: 2003-09-01
Genre:
ISBN: 9780954579401

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The Dual Frontiers of Cancer

The Dual Frontiers of Cancer
Author: Kieth S Miller
Publisher: Independently Published
Total Pages: 0
Release: 2024-06-08
Genre: Health & Fitness
ISBN:

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The Dual Frontiers of Cancer: Bridging the Gap Between Research and Treatment - Interplay of Signaling and the Tumor Microenvironment Immerse yourself in the revolutionary world of cancer research with "The Dual Frontiers of Cancer." This essential book explores the dynamic relationship between cancer signaling pathways and the tumor microenvironment, shedding light on the latest advancements in cancer treatment. - In-Depth Understanding: Uncover the molecular mechanisms behind cancer signaling and how researchers are developing innovative ways to target these pathways. - Microenvironment Dynamics: Learn about the critical role of the tumor microenvironment and how it influences cancer development and progression. - From Research to Treatment: See how groundbreaking discoveries are leading to new, more effective treatments that offer hope for patients worldwide. - Future Innovations: Get a glimpse into the future of cancer research, where emerging technologies and strategies promise to change the way we fight this disease. Whether you're a medical professional, researcher, student, or someone who wants to get informed about cancer, this book provides a comprehensive and accessible guide to the latest advancements in cancer biology. With engaging narratives and insightful analysis, "The Dual Frontiers of Cancer" bridges the gap between complex scientific concepts and practical treatment applications, making it a must-read for anyone interested in the future of cancer care.


Science, the Endless Frontier

Science, the Endless Frontier
Author: Vannevar Bush
Publisher: Princeton University Press
Total Pages: 186
Release: 2021-02-02
Genre: Science
ISBN: 069120165X

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The classic case for why government must support science—with a new essay by physicist and former congressman Rush Holt on what democracy needs from science today Science, the Endless Frontier is recognized as the landmark argument for the essential role of science in society and government’s responsibility to support scientific endeavors. First issued when Vannevar Bush was the director of the US Office of Scientific Research and Development during the Second World War, this classic remains vital in making the case that scientific progress is necessary to a nation’s health, security, and prosperity. Bush’s vision set the course for US science policy for more than half a century, building the world’s most productive scientific enterprise. Today, amid a changing funding landscape and challenges to science’s very credibility, Science, the Endless Frontier resonates as a powerful reminder that scientific progress and public well-being alike depend on the successful symbiosis between science and government. This timely new edition presents this iconic text alongside a new companion essay from scientist and former congressman Rush Holt, who offers a brief introduction and consideration of what society needs most from science now. Reflecting on the report’s legacy and relevance along with its limitations, Holt contends that the public’s ability to cope with today’s issues—such as public health, the changing climate and environment, and challenging technologies in modern society—requires a more capacious understanding of what science can contribute. Holt considers how scientists should think of their obligation to society and what the public should demand from science, and he calls for a renewed understanding of science’s value for democracy and society at large. A touchstone for concerned citizens, scientists, and policymakers, Science, the Endless Frontier endures as a passionate articulation of the power and potential of science.