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fMRI: From Nuclear Spins to Brain Functions

fMRI: From Nuclear Spins to Brain Functions
Author: Kamil Uludag
Publisher: Springer
Total Pages: 926
Release: 2015-09-16
Genre: Medical
ISBN: 1489975918

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This volume explores the revolutionary fMRI field from basic principles to state-of-the-art research. It covers a broad spectrum of topics, including the history of fMRI's development using endogenous MR blood contrast, neurovascular coupling, pulse sequences for fMRI, quantitative fMRI; fMRI of the visual system, auditory cortex, and sensorimotor system; genetic imaging using fMRI, multimodal neuroimaging, brain bioenergetics and function and molecular-level fMRI. Comprehensive and intuitively structured, this book engages the reader with a first-person account of the development and history of the fMRI field by the authors. The subsequent sections examine the physiological basis of fMRI, the basic principles of fMRI and its applications and the latest advances of the technology, ending with a discussion of fMRI’s future. fMRI: From Nuclear Spins to Brain Function, co-edited by leading and renowned fMRI researchers Kamil Ugurbil, Kamil Uludag and Lawrence Berliner, is an ideal resource for clinicians and researchers in the fields of neuroscience, psychology and MRI physics.


FMRI: From Nuclear Spins to Brain Functions

FMRI: From Nuclear Spins to Brain Functions
Author: Kamil Uludag
Publisher:
Total Pages:
Release: 2015
Genre:
ISBN: 9781489975928

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This book explores the revolutionary fMRI field from basic principles to state-of-the-art research. It covers a broad spectrum of topics, including the history of fMRI's development using endogenous MR blood contrast, neurovascular coupling, pulse sequences for fMRI, quantitative fMRI, genetic imaging using fMRI, multimodal neuroimaging, brain bioenergetics and function, and molecular-level fMRI. Comprehensive and intuitively structured, this book examines the physiological basis of fMRI, the basic principles of fMRI and its applications, and the latest advances of the technology. The final chapter discusses the field's future. fMRI: From Nuclear Spins to Brain Function is an ideal resource for clinicians and researchers in the fields of neuroscience, psychology, and MRI physics. This book also: · Explores a wide range of topics, covering the physical basics, physiological bases, a selection of various applications, and cutting-edge advances in fMRI · Engages the reader with a first-person account of the development and history of the fMRI field by the authors · Discusses fMRI applications in a variety of contexts, including fMRI of the visual system, auditory cortex, and sensorimotor system as well as the history of fMRI's development using endogenous MR blood contrast, neurovascular coupling, pulse sequences for fMRI, and quantitative fMRI .


Magnetic Resonance and Brain Function: Approaches from Physics

Magnetic Resonance and Brain Function: Approaches from Physics
Author: Società italiana di fisica
Publisher: IOS Press
Total Pages: 602
Release: 1999
Genre: Medical
ISBN: 161499224X

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In the last decade, NMR has set the basis for the understanding of the function and disfunction of the human brain. Particularly, Magnetic Resonance Imaging (MRI) has a leading position among the methodologies used for investigation and diagnostic of the Central Nervous System. In the 1990's the objective of finding new investigating means drove scientists towards different approaches, including: 1) Blood Oxygen Level Dependent (BOLD) MRI; 2) Double Magnetic Resonance (DMR); 3) Hyperpolarized Gases. These 3 methods are aimed at detecting brain metabolites with increasing sensitivity and resolution. This Enrico Fermi Course is of interest to researchers who work at the development of these interdisciplinary areas, i.e. physicists, chemists, engineers, but also the biomedical aspects of brain function in connection to the NMR potentialities.


Introduction to Functional Magnetic Resonance Imaging

Introduction to Functional Magnetic Resonance Imaging
Author: Richard B. Buxton
Publisher: Cambridge University Press
Total Pages: 542
Release: 2002-01-07
Genre: Medical
ISBN: 9780521581134

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Functional Magnetic Resonance Imaging (fMRI) is now a standard tool for mapping activation patterns in the human brain. This highly interdisciplinary field involves neuroscientists and physicists as well as clinicians who need to understand the rapidly increasing range, flexibility and sophistication of the techniques. In this book, Richard Buxton, a leading authority on fMRI, provides an invaluable introduction for this readership to how fMRI works, from basic principles and the underlying physics and physiology, to newer techniques such as arterial spin labeling and diffusion tensor imaging.


Functional magnetic resonance imaging (fMRI)

Functional magnetic resonance imaging (fMRI)
Author: Lori A. Whitten
Publisher: RTI Press
Total Pages: 36
Release: 2012-12-11
Genre: Medical
ISBN:

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The sophisticated methods of neuroscience—including molecular genetics, structural and functional neuroimaging, animal models, and experimental tasks that approximate real-world behaviors in human research—have yielded important insights about typical functioning and neurobehavioral disorders. Translational neuroscience endeavors to use this knowledge to improve the human condition by developing and improving interventions for these disorders. This paper reviews the literature on the contribution of functional magnetic resonance imaging (fMRI) and two related techniques, resting-state fMRI (rs-fMRI) and real-time fMRI (rt-fMRI), to the diagnosis and treatment of behavioral problems and psychiatric disorders. It also explains how incorporating neuroscience principles and techniques into research on the prevention of substance misuse and antisocial behavior may spur advances and innovations in this important area. This article argues that fMRI’s potential contribution to these prevention efforts has yet to be fully realized, explores new ways in which the technique could be adapted to that end, highlights some of the work by researchers in the vanguard of this effort, and notes limitations of fMRI and ethical concerns the technique raises.


fMRI

fMRI
Author: Stephan Ulmer
Publisher: Springer Science & Business Media
Total Pages: 181
Release: 2010-01-18
Genre: Medical
ISBN: 3540681329

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Functional MRI (fMRI) and the basic method of BOLD imaging were introduced in 1993 by Seiji Ogawa. From very basic experiments, fMRI has evolved into a clinical application for daily routine brain imaging. There have been various improvements in both the imaging technique as such as well as in the statistical analysis. In this volume, experts in the field share their knowledge and point out possible technical barriers and problems explaining how to solve them. Starting from the very basics on the origin of the BOLD signal, the book covers technical issues, anatomical landmarks, presurgical applications, and special issues in various clinical fields. Other modalities for brain mapping such as PET, TMS, and MEG are also compared with fMRI. This book is intended to give a state-of-the-art overview and to serve as a reference and guide for clinical applications of fMRI.


Make Life Visible

Make Life Visible
Author: Yoshiaki Toyama
Publisher: Springer Nature
Total Pages: 292
Release: 2019-10-02
Genre: Medical
ISBN: 9811379084

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This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.


Fundamentals of In Vivo Magnetic Resonance

Fundamentals of In Vivo Magnetic Resonance
Author: Daniel M. Spielman
Publisher: John Wiley & Sons
Total Pages: 293
Release: 2024-04-02
Genre: Science
ISBN: 1394233116

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Fundamentals of In Vivo Magnetic Resonance Authoritative reference explaining why and how the most important, radiation-free technique for elucidating tissue properties in the body works In Vivo Magnetic Resonance helps readers develop an understanding of the fundamental physical processes that take place inside the body that can be probed by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), uniquely bridging the gap between the physics of magnetic resonance (MR) image formation and the in vivo processes that influence the detected signals, thereby equipping the reader with the mathematical tools essential to study the spin interactions leading to various contrast mechanisms. With a focus on clinical relevance, this book equips readers with practical knowledge that can be directly applied in medical settings, enabling informed decision-making and advancements in the field of medical imaging. The material arises from the lecture notes for a Stanford University Department of Radiology course taught for over 15 years. Aided by clever illustrations, the book takes a step-by-step approach to explain complex concepts in a comprehensible manner. Readers can test their understanding by working on approximately 60 sample problems. Written by two highly qualified authors with significant experience in the field, In Vivo Magnetic Resonance includes information on: The fundamental imaging equations of MRI Quantum elements of magnetic resonance, including linear vector spaces, Dirac notation, Hilbert Space, Liouville Space, and associated mathematical concepts Nuclear spins, covering external and internal interactions, chemical shifts, dipolar coupling, J-coupling, the spin density operator, and the product operator formalism In vivo MR spectroscopy methods MR relaxation theory and the underlying sources of image contrast accessible via modern clinical MR imaging techniques With comprehensive yet accessible coverage of the subject and a wealth of learning resources included throughout, In Vivo Magnetic Resonance is an ideal text for graduate students in the fields of physics, biophysics, biomedical physics, and materials science, along with lecturers seeking classroom aids.


Ultra-Low Field Nuclear Magnetic Resonance

Ultra-Low Field Nuclear Magnetic Resonance
Author: Robert Kraus Jr.
Publisher: Oxford University Press
Total Pages: 266
Release: 2014-02-26
Genre: Medical
ISBN: 0199796513

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This book is designed to introduce the reader to the field of NMR/MRI at very low magnetic fields, from milli-Tesla to micro-Tesla, the ultra-low field (ULF) regime. The book is focused on applications to imaging the human brain, and hardware methods primarily based upon pre-polarization methods and SQUID-based detection. The goal of the text is to provide insight and tools for the reader to better understand what applications are best served by ULF NMR/MRI approaches. A discussion of the hardware challenges, such as shielding, operation of SQUID sensors in a dynamic field environment, and pulsed magnetic field generation are presented. One goal of the text is to provide the reader a framework of understanding the approaches to estimation and mitigation of low signal-to-noise and long imaging time, which are the main challenges. Special attention is paid to the combination of MEG and ULF MRI, and the benefits and challenges presented by trying to accomplish both with the same hardware. The book discusses the origin of unique relaxation contrast at ULF, and special considerations for image artifacts and how to correct them (i.e. concomitant gradients, ghost artifacts). A general discussion of MRI, with special consideration to the challenges of imaging at ULF and unique opportunities in pulse sequences, is presented. The book also presents an overview of some of the primary applications of ULF NMR/MRI being pursued.