Aziridines And Epoxides In Organic Synthesis PDF Download
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Author | : Andrei K. Yudin |
Publisher | : John Wiley & Sons |
Total Pages | : 532 |
Release | : 2006-02-20 |
Genre | : Science |
ISBN | : 9783527312139 |
Download Aziridines and Epoxides in Organic Synthesis Book in PDF, ePub and Kindle
Aziridines and epoxides are among the most widely used intermediates in organic synthesis, acting as precursors to complex molecules due to the strains incorporated in their skeletons. Besides their importance as reactive intermediates, many biologically active compounds also contain these three-membered rings. Filling a gap in the literature, this clearly structured book presents the much needed information in a compact and concise way. The renowned editor has succeeded in gathering together excellent authors to cover synthesis, applications, and the biological aspects in equal depth. Divided roughly equally between aziridines and epoxides, the twelve chapters discuss: * Synthesis of aziridines * Nucleophilic ring-opening of aziridines and epoxides * Organic synthesis with aziridine building blocks * Vinyl aziridines in organic synthesis * Diastereoselective aziridination reagents * Synthetic aspects of aziridinomitocene chemistry * Biosynthesis of biologically important aziridines * Organic catalysis of epoxide and aziridine ring formation * Metal-mediated synthesis of epoxides * Asymmetric epoxide ring opening chemistry * Epoxides in complex molecule synthesis * Biological activity of epoxide-containing molecules A high-quality reference manual for academic and industrial chemists alike.
Author | : Andrei K. Yudin |
Publisher | : John Wiley & Sons |
Total Pages | : 516 |
Release | : 2006-12-13 |
Genre | : Science |
ISBN | : 352760748X |
Download Aziridines and Epoxides in Organic Synthesis Book in PDF, ePub and Kindle
Aziridines and epoxides are among the most widely used intermediates in organic synthesis, acting as precursors to complex molecules due to the strains incorporated in their skeletons. Besides their importance as reactive intermediates, many biologically active compounds also contain these three-membered rings. Filling a gap in the literature, this clearly structured book presents the much needed information in a compact and concise way. The renowned editor has succeeded in gathering together excellent authors to cover synthesis, applications, and the biological aspects in equal depth. Divided roughly equally between aziridines and epoxides, the twelve chapters discuss: * Synthesis of aziridines * Nucleophilic ring-opening of aziridines and epoxides * Organic synthesis with aziridine building blocks * Vinyl aziridines in organic synthesis * Diastereoselective aziridination reagents * Synthetic aspects of aziridinomitocene chemistry * Biosynthesis of biologically important aziridines * Organic catalysis of epoxide and aziridine ring formation * Metal-mediated synthesis of epoxides * Asymmetric epoxide ring opening chemistry * Epoxides in complex molecule synthesis * Biological activity of epoxide-containing molecules A high-quality reference manual for academic and industrial chemists alike.
Author | : Navjeet Kaur |
Publisher | : Elsevier |
Total Pages | : 354 |
Release | : 2024-01-13 |
Genre | : Science |
ISBN | : 0443220603 |
Download Synthesis of Aziridines and Oxaziridines from Imines Book in PDF, ePub and Kindle
The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures. The synthetic community is captivated with prospects of selective synthesis and conversions of aziridines. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine. Synthesis of Aziridines and Oxaziridines from Imines describes the new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases. Focuses on the biological importance of different heterocycles Describes traditional and innovative methods for the synthesis of aziridines from imines Includes comparison amongst different methods, reagents, reaction conditions in tabulated forms, advantages, disadvantages, and critical analysis of different methodologies with respect to their comparison with green technique
Author | : Rick Reeves |
Publisher | : |
Total Pages | : 0 |
Release | : 2018 |
Genre | : Epoxy compounds |
ISBN | : 9781536129601 |
Download Epoxides Book in PDF, ePub and Kindle
This book opens with a discussion on the syntheses of acyclic polyketides by using epoxide opening reactions. The stereoselective epoxidations of allylic alcohols, including catalytic asymmetric epoxidation reactions and stereospecific reactions due to substrate-control, are described shortly. Afterwards, different epoxide opening reactions and applications in natural product synthesis are reviewed. The authors highlight the recent advances in catalytic one-pot synthesis of epoxides. The versatility of organometallic catalysts in epoxidation of alkenes are considered an important point of research in the context of these transformations. Later, occurrence of carotenoid 5,6-epoxides, their chemical synthesis, the separation of stereoisomers, some transformations of 5,6-epoxy-carotenoids, and their biological processes are described. Following this, the methodologies for the deoxygenation of epoxides using oxo-molybdenum and oxo-rhenium complexes as efficient catalysts are described, allowing a large community of readers, in particularly the community that works in catalysis, organic and organometallic chemistry, ready access to the novel methodologies developed.
Author | : Helen M. I. Osborn |
Publisher | : |
Total Pages | : |
Release | : 1994 |
Genre | : |
ISBN | : |
Download Activated Aziridines as Versatile Intermediates Organic Synthesis Book in PDF, ePub and Kindle
Author | : Hélène Pellissier |
Publisher | : John Wiley & Sons |
Total Pages | : 800 |
Release | : 2017-03-28 |
Genre | : Science |
ISBN | : 3527802037 |
Download Asymmetric Synthesis of Three-Membered Rings Book in PDF, ePub and Kindle
The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.
Author | : Navjeet Kaur |
Publisher | : Elsevier |
Total Pages | : 0 |
Release | : 2025-02-01 |
Genre | : Science |
ISBN | : 9780443316005 |
Download Synthesis of Epoxides Book in PDF, ePub and Kindle
Synthesis of Epoxides explores different ways of making epoxides, both old and new, and delves into the growing field of heterocyclic chemistry. It's aimed at people who want a variety of methods and need help figuring out which one suits their specific needs. For students, having all the protocols for making epoxides in one place is handy because sometimes you just want to see all the options for creating a particular compound from a specific starting point. Diazo compounds are important synthetic intermediates in organic synthesis but, because of their unpredictable explosive nature and toxicity, their unique reactivity has not been fully exploited and their employment on large scale is avoided. The synthetic usefulness of diazo compounds cannot be overlooked despite their danger. Because of their ylide and 1,3-dipole nature, the diazo compounds have a unique reactivity. The diazo compounds can be utilized for various different conversions including S-ylide-assisted epoxidation, cyclopropanation, or aziridination reactions. This book describes the new and classic methods for the synthesis of epoxides and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will learn about different methods and want information allowing them to evaluate which method is most suitable in particular cases. Students will be able to find the protocols for the synthesis of epoxides in one place within this book because sometimes we want to see all of the possibilities for synthesizing a particular compound from one particular substrate.
Author | : Yang Zhao |
Publisher | : |
Total Pages | : 169 |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Nickel-catalyzed Reductive Coupling of Epoxides and Aziridines Book in PDF, ePub and Kindle
"In this thesis, nickel-catalyzed reductive coupling reaction with epoxides and aziridines is described with details. Chapter 1 delves into the development of nickel/iodide-catalyzed epoxide arylation reaction. The broad utilization and nucleophilic ring opening of epoxides are both covered. In particular, the chapter presents the challenges and practicality associated with the catalysis. In-depth discussion is devoted to the discovery of the catalysis and detailed optimization and substrate scope are also covered. Chapter 2 introduces the history of Nugent's reagent and its application in epoxide-related chemistry. It also explains the logic and design for the Ni/Ti co-catalyzed epoxide arylation reaction. Chapter 3 deepens the discussion in Chapter 2 by extending the Ni/Ti co-catalysis to enantioselective synthesis. Chiral catalyst synthesis, kinetic resolution, and heterocyclic arene application are all covered. Chapter 4 details the application of Ni/Iodide catalysis to aziridines. Interesting Lewis acid effect and protecting group screen are explained with details. The substrate scope of this reaction is also briefly discussed."--Page vii.
Author | : |
Publisher | : Newnes |
Total Pages | : 9815 |
Release | : 2014-02-14 |
Genre | : Science |
ISBN | : 008097743X |
Download Comprehensive Organic Synthesis Book in PDF, ePub and Kindle
The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively
Author | : Atta-ur-Rahman |
Publisher | : Bentham Science Publishers |
Total Pages | : 268 |
Release | : 2018-08-01 |
Genre | : Science |
ISBN | : 1681086956 |
Download Advances in Organic Synthesis Book in PDF, ePub and Kindle
Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. This volume presents the following reviews: • Asymmetric hydrogenation of tetrasubstituted olefins • Recent advances in catalytic organic synthesis applications of covalently supported ionic liquids • Recent developments in intramolecular cyclization reactions via carbon-heteroatom (c-x) bond formation • Efficient synthetic protocol and mechanistic study of quinazoline analogues and their biological importance • Synthesis of N,O,S-heterocycles by one-pot reactions of epoxides, aziridines and oxaziridines