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Avian Diagnostic and Therapeutic Antibodies to Viral Emerging Pathogens

Avian Diagnostic and Therapeutic Antibodies to Viral Emerging Pathogens
Author:
Publisher:
Total Pages: 3
Release: 2011
Genre:
ISBN:

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During the current period the following key objectives were achieved: demonstration of high titer antibody production by geese following immunization with inactived H1N1 virus; completion of the epitope mapping of West Nile Virus-specific goose antibodies and initiation of epitope mapping of H1N1 flu-specific goose antibodies; advancement in scalable purification of goose antibodies.


Avian Diagnostic and Therapeutic Antibodies

Avian Diagnostic and Therapeutic Antibodies
Author:
Publisher:
Total Pages:
Release: 2012
Genre:
ISBN:

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A number of infectious agents have the potential of causing significant clinical symptomology and even death, but dispite this, the number of incidence remain below the level that supports producing a vaccine. Therapeutic antibodies provide a viable treatment option for many of these diseases. We proposed that antibodies derived from West Nile Virus (WNV) immunized geese would be able to treat WNV infection in mammals and potential humans. We demonstrated that WNV specific goose antibodies are indeed successful in treating WNV infection both prophylactically and therapeutically in a golden hamster model. We demonstrated that the goose derived antibodies are non-reactogenic, i.e. do not cause an inflammatory response with multiple exposures in mammals. We also developed both a specific pathogen free facility to house the geese during the antibody production phase and a patent-pending purification process to purify the antibodies to greater than 99% purity. Therefore, the success of these study will allow a cost effective rapidly producible therapeutic toward clinical testing with the necessary infrastructure and processes developed and in place.


Diagnostic Imaging of Emerging Infectious Diseases

Diagnostic Imaging of Emerging Infectious Diseases
Author: Pu-Xuan Lu
Publisher: Springer
Total Pages: 225
Release: 2015-11-26
Genre: Medical
ISBN: 9401773637

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This book introduces the diagnosis of Emerging Infectious Diseases (EIDs), including newly emerging infectious diseases and also infectious diseases that show resistance to present treatments. Radiographic examinations are of great value in EIDs diagnosis, differential diagnosis, treatment efficacy assessment and prognosis evaluation. This book covers severe acute respiratory syndrome (SARS), human avian influenza (H5N1, H7N9), influenza A (H1N1), hand-foot-mouth disease, acquired immune deficiency syndrome (AIDS), viral hepatitis, pulmonary tuberculosis. All seven of these EIDs are associated with high incidence and mortality. This book details the imaging techniques, radiological appearance and characteristics of EIDs, and diagnosis and differential diagnosis of EID-related complications. Considering the unique and in some cases only partially understood nature of EIDs, appropriate space is provided in this book for the detailed explanation of the etiology, epidemiology, pathophysiology, clinical symptoms and signs, laboratory tests, clinical diagnosis and differential diagnosis, prevention, treatment, and prognosis of EIDs. As such, it will be a valuable resource for improving the prevention, diagnosis, and treatment of EIDs. Editors Pu-Xuan Lu and Bo-Ping Zhou are professors at Shenzhen Third People's Hospital, Guangdong Medical College, China.


Bird Flu

Bird Flu
Author: Viroj Wiwanitkit
Publisher: Nova Publishers
Total Pages: 194
Release: 2008
Genre: Medical
ISBN: 9781604562385

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This book focuses on the "Bird Flu: the new emerging infectious disease", a new health problem, and the aspects relating to the use of tropical medicine. It specifically covers the clinical aspects, scientific laboratory, public health, as well as the social sciences relating to this new important infectious disease. Mainly, the book presents summative data from the molecular to the population scales, as well as additional metanalysis for important topics. In addition, the diagnostic guideline and clinical practice guidelines of the mentioned conditions are detailed. There is still limited knowledge on this topic while the wider distribution of the disorder due to the globalisation can be expected.


Emerging Viral Diseases

Emerging Viral Diseases
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 310
Release: 2015-03-19
Genre: Medical
ISBN: 0309314003

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In the past half century, deadly disease outbreaks caused by novel viruses of animal origin - Nipah virus in Malaysia, Hendra virus in Australia, Hantavirus in the United States, Ebola virus in Africa, along with HIV (human immunodeficiency virus), several influenza subtypes, and the SARS (sudden acute respiratory syndrome) and MERS (Middle East respiratory syndrome) coronaviruses - have underscored the urgency of understanding factors influencing viral disease emergence and spread. Emerging Viral Diseases is the summary of a public workshop hosted in March 2014 to examine factors driving the appearance, establishment, and spread of emerging, re-emerging and novel viral diseases; the global health and economic impacts of recently emerging and novel viral diseases in humans; and the scientific and policy approaches to improving domestic and international capacity to detect and respond to global outbreaks of infectious disease. This report is a record of the presentations and discussion of the event.


Selected Studies on Avian RNA Viruses

Selected Studies on Avian RNA Viruses
Author: Itamar D. Villanueva
Publisher:
Total Pages:
Release: 2010
Genre:
ISBN:

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There are many pathogens that infect birds and perhaps many more that researchers have not yet identified. Of all potential pathogens, the research presented in this manuscript focuses on two avian RNA viruses. First, a serodiagnostic test for newly described Avian Borna Virus (ABV), which has been recently identified as the etiological agent of Proventricular Dilatation Disease (PDD), was developed. PDD is a deadly disease which affects many birds, but to this point, has mainly been a concern of psittacines. The need for a diagnostic test is imperative. An antigen associated with PDD was identified from the brains of affected birds by use of the Western blot assay. This antigen was subsequently purified using various protein purification protocols, including a modification of reverse-phase chromatography. The antigen was then identified as the ABV nucleoprotein according to tandem mass spectroscopy analysis and protein database search. A serodiagnostic assay was developed and standardized using infected cell culture as an antigen source. Over 100 avian serum samples were submitted by veterinarians to test for the presence of antibodies against ABV nucleoprotein. This serodiagnostic assay was found to have 90% sensitivity and 82% specificity for the diagnosis of ABV in infected birds. Second, the ability of a carbohydrate epitope to enhance the humoral immune response to an influenza vaccine was tested in chickens. Influenza is a serious infection that causes 36,000 deaths annually in the United States. The need for a more efficacious is addressed by incorporating a carbohydrate antigen targeted by natural antibodies that are produced by chickens as well as humans. Therefore, chickens may be a suitable animal model to test this hypothesis. Influenza vaccines with alpha-gal antigen are prepared from cell culture. The antigen is then enzymatically removed from some vaccines and the nature of the ensuing humoral immune response to these vaccines in chickens is attempted. Though ABV is not known to be zoonotic at this time, zoonotic infections pose the highest risk as new and emerging infectious diseases in the human population. The following research contains applications relative to challenges faced by researchers and clinicians in infectious disease containment.


Avian Influenza in Human

Avian Influenza in Human
Author: Chen Qiu
Publisher: Springer
Total Pages: 190
Release: 2022-06-16
Genre: Medical
ISBN: 9789811614316

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Some avian influenza viruses can infect humans, cause disease, and even result in deaths. This book comprehensively and systematically presents the theory, diagnosis and clinical treatment of typical avian influenza viruses in human. The first chapters introduce the ethiology, epidemiology, clinical diagnosis and treatment of human avian influenza and complications. The following chapters include overview, extensive images, differential diagnosis and clinical cases of H7N9, H5N1, H5N6, H10N8, H9N2 and H7N4 avian influenza. Written by practitioners directly involved in the prevention and clinical treatment of human avian influenza, it will be an invaluable aid for practitioners in centers for infectious disease control and prevention, hospitals, and academic institutions to improve prevention, diagnosis and treatment of avian influenza in human.


Global Infectious Disease Surveillance and Detection

Global Infectious Disease Surveillance and Detection
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 284
Release: 2007-11-11
Genre: Medical
ISBN: 0309111145

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Early detection is essential to the control of emerging, reemerging, and novel infectious diseases, whether naturally occurring or intentionally introduced. Containing the spread of such diseases in a profoundly interconnected world requires active vigilance for signs of an outbreak, rapid recognition of its presence, and diagnosis of its microbial cause, in addition to strategies and resources for an appropriate and efficient response. Although these actions are often viewed in terms of human public health, they also challenge the plant and animal health communities. Surveillance, defined as "the continual scrutiny of all aspects of occurrence and spread of a disease that are pertinent to effective control", involves the "systematic collection, analysis, interpretation, and dissemination of health data." Disease detection and diagnosis is the act of discovering a novel, emerging, or reemerging disease or disease event and identifying its cause. Diagnosis is "the cornerstone of effective disease control and prevention efforts, including surveillance." Disease surveillance and detection relies heavily on the astute individual: the clinician, veterinarian, plant pathologist, farmer, livestock manager, or agricultural extension agent who notices something unusual, atypical, or suspicious and brings this discovery in a timely way to the attention of an appropriate representative of human public health, veterinary medicine, or agriculture. Most developed countries have the ability to detect and diagnose human, animal, and plant diseases. Global Infectious Disease Surveillance and Detection: Assessing the Challenges-Finding Solutions, Workshop Summary is part of a 10 book series and summarizes the recommendations and presentations of the workshop.


Emerging Infectious Diseases

Emerging Infectious Diseases
Author:
Publisher:
Total Pages: 694
Release: 2007
Genre: Communicable diseases
ISBN:

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