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Avian Diagnostic and Therapeutic Antibodies

Avian Diagnostic and Therapeutic Antibodies
Author:
Publisher:
Total Pages:
Release: 2012
Genre:
ISBN:

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A number of infectious agents have the potential of causing significant clinical symptomology and even death, but dispite this, the number of incidence remain below the level that supports producing a vaccine. Therapeutic antibodies provide a viable treatment option for many of these diseases. We proposed that antibodies derived from West Nile Virus (WNV) immunized geese would be able to treat WNV infection in mammals and potential humans. We demonstrated that WNV specific goose antibodies are indeed successful in treating WNV infection both prophylactically and therapeutically in a golden hamster model. We demonstrated that the goose derived antibodies are non-reactogenic, i.e. do not cause an inflammatory response with multiple exposures in mammals. We also developed both a specific pathogen free facility to house the geese during the antibody production phase and a patent-pending purification process to purify the antibodies to greater than 99% purity. Therefore, the success of these study will allow a cost effective rapidly producible therapeutic toward clinical testing with the necessary infrastructure and processes developed and in place.


Avian Diagnostic and Therapeutic Antibodies to Viral Emerging Pathogens

Avian Diagnostic and Therapeutic Antibodies to Viral Emerging Pathogens
Author:
Publisher:
Total Pages: 3
Release: 2011
Genre:
ISBN:

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During the current period the following key objectives were achieved: demonstration of high titer antibody production by geese following immunization with inactived H1N1 virus; completion of the epitope mapping of West Nile Virus-specific goose antibodies and initiation of epitope mapping of H1N1 flu-specific goose antibodies; advancement in scalable purification of goose antibodies.


Current Therapy in Avian Medicine and Surgery

Current Therapy in Avian Medicine and Surgery
Author: Brian Speer
Publisher: Elsevier Health Sciences
Total Pages: 929
Release: 2015-12-04
Genre: Medical
ISBN: 1455746711

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A current and cutting-edge reference, Current Therapy in Avian Medicine and Surgery takes the popular Current Therapy approach in providing succinct and clear information pertinent to the medical care of avian species. Most chapters include an up-to-date delivery of the current state of knowledge on their subject material, and provide practical approaches and thought processes applicable to diagnosis and therapy where appropriate. Information is always easy to find, with topics including the latest advances in internal medicine; behavioral medicine; anesthesia, analgesia, and surgery. Sections dedicated to welfare, conservation, and practice risk management explore important, but less commonly discussed aspects of avian practice; and the pattern recognition portion of the text offers readers a view of what companion bird conditions are likely to be seen in practice in different parts of the world. Written by a team of highly regarded contributors from around the world, this text helps readers, regardless of location and current knowledge, develop and augment skills in the medical and surgical care of avian species. The Current Therapy format provides current, up-to-date, succinct and clear information pertinent to the medical and surgical care of avian species. Coverage of clinically significant topics includes current veterinary scientific literature and hot topics relating to today's avian medicine and surgery. Coverage of a wide variety of bird species includes psittacines, pigeons, raptors, ratites, waterfowl, gallinaceous birds, and less common species. More than 800 full-color images show avian disease, management strategies and thought processes, and aid in formulating guidelines to care. World-renowned, expert contributors provide cutting-edge information, offering authoritative, accurate, and sometimes controversial opinions in many areas of study. Summary tables simplify the lookup of key facts and treatment guidelines. References in each chapter facilitate further reading and research on specific topics.


Avian Influenza

Avian Influenza
Author: Sandra Sapats
Publisher:
Total Pages: 52
Release: 2014
Genre:
ISBN: 9781742546841

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Therapeutic Antibodies

Therapeutic Antibodies
Author: John Landon
Publisher: Springer Science & Business Media
Total Pages: 358
Release: 2012-12-06
Genre: Medical
ISBN: 1447119371

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Several aspects of clinical medicine are poised on the edge of a new era with the introduction of therapeutic antibodies. This revolution has been made possible by major advances in immune technology, which are now beginning to mature into clinical practice. This volume is aimed at all clinicians involved with this form of treatment, especially accident and emergency physicians, clinical immunologists, and pharmacologists. It covers both the basic technology, and also all the main clinical areas of application: septic shock, auto-immune disease, and cancer. The future of therapeutic antibodies is also discussed, including exciting new developments in "catalytic antibodies". This is the first occasion on which all these topics have been brought together in a single volume, thus making it an important reference source for physicians and researchers in this fast-moving area.


Avian Immunology

Avian Immunology
Author: Bernd Kaspers
Publisher: Academic Press
Total Pages: 0
Release: 2012-12-02
Genre: Medical
ISBN: 9780123972729

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The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research