Approaches To The Purification Analysis And Characterization Of Antibody Based Therapeutics PDF Download
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| Author | : Allan Matte |
| Publisher | : Elsevier |
| Total Pages | : 222 |
| Release | : 2020-09-07 |
| Genre | : Business & Economics |
| ISBN | : 0081030193 |
Download Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics Book in PDF, ePub and Kindle
Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography
| Author | : Mohammad A. Tabrizi |
| Publisher | : Springer |
| Total Pages | : 248 |
| Release | : 2018-09-11 |
| Genre | : Medical |
| ISBN | : 9811304963 |
Download Development of Antibody-Based Therapeutics Book in PDF, ePub and Kindle
With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.
| Author | : Uwe Gottschalk |
| Publisher | : John Wiley & Sons |
| Total Pages | : 344 |
| Release | : 2011-09-20 |
| Genre | : Medical |
| ISBN | : 1118210743 |
Download Process Scale Purification of Antibodies Book in PDF, ePub and Kindle
Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling becomes economically unsupportable. This book offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification. The book has wide coverage of different antibody purification strategies and brings together top-tier experts to address problems in process-scale antibody purification.
| Author | : Allan Matte |
| Publisher | : Elsevier |
| Total Pages | : 224 |
| Release | : 2020-08-20 |
| Genre | : Business & Economics |
| ISBN | : 0128186577 |
Download Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics Book in PDF, ePub and Kindle
Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography
| Author | : John E. Schiel |
| Publisher | : ACS Symposium |
| Total Pages | : 0 |
| Release | : 2016-06-24 |
| Genre | : Medical |
| ISBN | : 9780841230293 |
Download State-Of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 2. Biopharmaceutical Characterization Book in PDF, ePub and Kindle
"Distributed in print by Oxford University Press."
| Author | : Guodong Chen |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 408 |
| Release | : 2014-07-08 |
| Genre | : Science |
| ISBN | : 1441978623 |
Download Characterization of Protein Therapeutics using Mass Spectrometry Book in PDF, ePub and Kindle
This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.
| Author | : Mario L. Rocci Jr. |
| Publisher | : Springer |
| Total Pages | : 239 |
| Release | : 2017-04-24 |
| Genre | : Medical |
| ISBN | : 3319548026 |
Download Regulated Bioanalysis: Fundamentals and Practice Book in PDF, ePub and Kindle
The editors have engaged leading scientists in the field to participate in the development of this book, which is envisioned as a “one of a kind” contribution to the field. The book is a comprehensive text that puts fundamental bioanalytical science in context with current practice, its challenges and ongoing developments. It expands on existing texts on the subject by covering regulated bioanalysis of both small and large molecule therapeutics from both a scientific and regulatory viewpoint. The content will be useful to a wide spectrum of readers: from those new to bioanalysis; to those developing their experience in the laboratory, or working in one of the many critical supporting roles; to seasoned practitioners looking for a solid source of information on this exciting and important discipline.
| Author | : Kurt Brorson |
| Publisher | : |
| Total Pages | : 62 |
| Release | : 2008 |
| Genre | : |
| ISBN | : 9780939459230 |
Download Virus filtration Book in PDF, ePub and Kindle
| Author | : Barry S. Selinsky |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 330 |
| Release | : 2008-02-03 |
| Genre | : Science |
| ISBN | : 159259400X |
Download Membrane Protein Protocols Book in PDF, ePub and Kindle
Knowledge of the three-dimensional structure of a protein is absolutely required for the complete understanding of its function. The spatial orientation of amino acids in the active site of an enzyme demonstrates how substrate specificity is defined, and assists the medicinal chemist in the design of s- cific, tight-binding inhibitors. The shape and contour of a protein surface hints at its interaction with other proteins and with its environment. Structural ana- sis of multiprotein complexes helps to define the role and interaction of each individual component, and can predict the consequences of protein mutation or conditions that promote dissociation and rearrangement of the complex. Determining the three-dimensional structure of a protein requires milligram quantities of pure material. Such quantities are required to refine crystallization conditions for X-ray analysis, or to overcome the sensitivity limitations of NMR spectroscopy. Historically, structural determination of proteins was limited to those expressed naturally in large amounts, or derived from a tissue or cell source inexpensive enough to warrant the use of large quantities of cells. H- ever, with the advent of the techniques of modern gene expression, many p- teins that are constitutively expressed in minute amounts can become accessible to large-scale purification and structural analysis.
| Author | : William R Strohl |
| Publisher | : Elsevier |
| Total Pages | : 697 |
| Release | : 2012-10-16 |
| Genre | : Medical |
| ISBN | : 1908818093 |
Download Therapeutic Antibody Engineering Book in PDF, ePub and Kindle
The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity
