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| Author | : Eugene E. Harris (Professor) |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 249 |
| Release | : 2015 |
| Genre | : Science |
| ISBN | : 0199978034 |
Geneticist Eugene Harris presents us with the complete and up-to-date account of the evolution of the human genome.
| Author | : Constance B. Hilliard |
| Publisher | : Harvard University Press |
| Total Pages | : 209 |
| Release | : 2024 |
| Genre | : Medical |
| ISBN | : 0674268601 |
Race is a social reality, not a biological one. Yet African Americans are poorly served by even advanced genetic medicine because it is built on European DNA. Constance Hilliard explores the benefits and drawbacks of racial heuristics in medicine and argues for nonessentializing methods of harnessing genomic science on behalf of people of color.
| Author | : Constance B. Hilliard |
| Publisher | : Harvard University Press |
| Total Pages | : 209 |
| Release | : 2024-04-16 |
| Genre | : Social Science |
| ISBN | : 067429677X |
A leading evolutionary historian offers a radical solution to racial health disparities in the United States. Constance B. Hilliard was living in Japan when she began experiencing joint pain. Her doctor diagnosed osteoarthritis—a common ailment for someone her age. But her bloodwork showed something else: Hilliard, who had never had kidney problems, appeared to be suffering from renal failure. When she returned to Texas, however, a new round of tests showed that her kidneys were healthy. Unlike the Japanese doctor, her American primary care provider had checked a box on her lab report for “African American.” As a scholar of scientific racism, Hilliard was perplexed. Why should race, which experts agree has no biological basis, matter for getting accurate test results? Ancestral Genomics is the result of Hilliard’s decade-long quest to solve this puzzle. In a masterful synthesis of evolutionary history, population genetics, and public health research, she addresses the usefulness of race as a heuristic in genomic medicine. Built from European genetic data, the Human Genome Project and other databases have proven inadequate for identifying disease-causing gene variants in patients of African descent. Such databases, Hilliard argues, overlook crucial information about the environments to which their ancestors’ bodies adapted prior to the transatlantic slave trade. Hilliard shows how, by analyzing “ecological niche populations,” a classification model that combines family and ecological histories with genetic information, our increasingly advanced genomic technologies, including personalized medicine, can serve African Americans and other people of color, while avoiding racial essentialism. Forcefully argued and morally urgent, Ancestral Genomics is a clarion call for the US medical community to embrace our multigenomic society.
| Author | : Rene J. Herrera |
| Publisher | : Academic Press |
| Total Pages | : 588 |
| Release | : 2018-06-13 |
| Genre | : Science |
| ISBN | : 0128041285 |
Ancestral DNA, Human Origins, and Migrations describes the genesis of humans in Africa and the subsequent story of how our species migrated to every corner of the globe. Different phases of this journey are presented in an integrative format with information from a number of disciplines, including population genetics, evolution, anthropology, archaeology, climatology, linguistics, art, music, folklore and history. This unique approach weaves a story that has synergistic impact in the clarity and level of understanding that will appeal to those researching, studying, and interested in population genetics, evolutionary biology, human migrations, and the beginnings of our species. Integrates research and information from the fields of genetics, evolution, anthropology, archaeology, climatology, linguistics, art, music, folklore and history, among others Presents the content in an entertaining and synergistic style to facilitate a deep understanding of human population genetics Informs on the origins and recent evolution of our species in an approachable manner
| Author | : Joshua Z. Rappoport |
| Publisher | : BenBella Books |
| Total Pages | : 249 |
| Release | : 2020-07-07 |
| Genre | : Technology & Engineering |
| ISBN | : 1950665259 |
"A good companion for those with a science background interested in learning more about human genetics." —Booklist Thanks to the popularity of personal genetic testing services, it's now easier than ever to get information about our own unique DNA—but who does this information really benefit? And, as genome editing and gene therapy transform the healthcare landscape, what do we gain—and what might we give up in return? Inside each of your cells is the nucleus, a small structure that contains all of the genetic information encoded by the DNA inside, your genome. Not long ago, the first human genome was sequenced at a cost of nearly $3 billion; now, this same test can be done for about $1,000. This new accessibility of genome sequence information creates huge potential for advances in how we understand and treat disease, among other things. It also raises significant concerns regarding ethics and personal privacy. In Mapping Humanity: How Modern Genetics Is Changing Criminal Justice, Personalized Medicine, and Our Identities, cellular biology expert Joshua Z. Rappoport provides a detailed look at how the explosion in genetic information as a result of cutting-edge technologies is changing our lives and our world. Inside, discover: • An in-depth look at how your personal genome creates the unique individual that you are • How doctors are using DNA sequencing to identify the underlying genetic causes of disease • Why the field of gene therapy offers amazing potential for medical breakthroughs—and why it's taking so long • The fantastic potential—and troubling concerns—surrounding genome editing • The real impact—and validity—of popular personal genetic testing products, such as 23andMe • Details of how molecular biology and DNA are changing the criminal justice system • Facts you should know about Genetically Modified Organisms (GMOs) Throughout, in compelling, accessible prose, Rappoport explores the societal, ethical, and economic impacts of this new era. Offering a framework for balancing the potential risks and benefits of genetic information technologies and genetic engineering, Mapping Humanity is an indispensable guide to navigating the possibilities and perils of our gene-centric future.
| Author | : Julien Y Dutheil |
| Publisher | : |
| Total Pages | : 464 |
| Release | : 2020-10-08 |
| Genre | : Science |
| ISBN | : 9781013271403 |
This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including demography inference, population structure analysis and detection of selection, using both model-based inference and simulation procedures. Last but not least, it offers an overview of the current knowledge acquired by applying such methods to a large variety of eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, pointers to the relevant literature, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Statistical Population Genomics aims to promote and ensure successful applications of population genomic methods to an increasing number of model systems and biological questions. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
| Author | : David A Liberles |
| Publisher | : OUP Oxford |
| Total Pages | : 266 |
| Release | : 2007-05-31 |
| Genre | : Science |
| ISBN | : 0191538418 |
Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields. Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including whole proteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized to provide insights and inform future research. This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics.
| Author | : Daniel L. Hartl |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 313 |
| Release | : 2020 |
| Genre | : Science |
| ISBN | : 0198862296 |
This accessible primer has been completely revised and updated to provide a concise but comprehensive introduction to the basic concepts of population genetics and genomics.
| Author | : Barbara A. Koenig |
| Publisher | : |
| Total Pages | : 402 |
| Release | : 2008 |
| Genre | : Science |
| ISBN | : |
With the completion of the sequencing of the human genome in 2001, the debate over the existence of a biological basis for race has been revived. Interdisciplinary scholars here examine the new social, political and ethical concerns that are attached to how we think about emerging technologies and their impact on conceptions of race.
| Author | : Alan R. Templeton |
| Publisher | : Academic Press |
| Total Pages | : 498 |
| Release | : 2018-11-08 |
| Genre | : Science |
| ISBN | : 0123860261 |
Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed. Comprehensively explains the use of population genetics and genomics in medical applications and research Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposals Provides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now
