Analysis And Manipulation Of Autoreactive And Tumor Specific T Cell Responses PDF Download
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Author | : Jelena Petrović |
Publisher | : |
Total Pages | : 59 |
Release | : 2004 |
Genre | : |
ISBN | : 9789171401564 |
Download Analysis and Manipulation of Autoreactive and Tumor-Specific T Cell Responses Book in PDF, ePub and Kindle
Author | : Dirk Nagorsen |
Publisher | : Springer Science & Business Media |
Total Pages | : 313 |
Release | : 2006-01-16 |
Genre | : Medical |
ISBN | : 140203623X |
Download Analyzing T Cell Responses Book in PDF, ePub and Kindle
Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc. in combination with various adjuvants and carriers are being evaluated in clinical trials (1-3). To determine the optimal cancer vaccine strategy, a surrogate immunological end-point that correlates with clinical outcome needs to be defined, since it would facilitate the rapid comparison of these various formulations. Traditional immunological assays such as ELISA, proliferation and cytotoxicity assays can detect immune responses in vaccinated patients but are not quantitative. In contrast, novel assays such as enzyme-linked immunospot (ELISPOT) assay, intracellular cytokine assay and tetramer assay can quantitate the frequency of antigen-specific T cells. Of these, the ELISPOT assay has the 5 lowest detection limit with 1/10 peripheral blood mononuclear cells (PBMC) and has been determined to be one of the most useful assays to evaluate immune response to cancer vaccines (4). However, the IFN-? ELISPOT assay is not an exclusive measure of cytotoxic T-lymphocyte (CTL) activity as non-cytotoxic cells can also secrete IFN-?. Additionally, CTL with lytic activity do not always secrete IFN-? (5). A more relevant approach to assess functional activity of cytotoxic lymphocytes would be to measure the secretion of molecules that are associated with lytic activity. One of the major mechanisms of cell-mediated cytotoxicity involves exocytosis of cytoplasmic granules from the effector toward the target cell.
Author | : Shuiping Jiang |
Publisher | : Springer Science & Business Media |
Total Pages | : 606 |
Release | : 2008-12-14 |
Genre | : Medical |
ISBN | : 0387779094 |
Download Regulatory T Cells and Clinical Application Book in PDF, ePub and Kindle
Covering one of the hottest topics in immunology today, this book provides a comprehensive view of all types of regulatory T cells described so far in the literature. The book will have broad appeal to both researchers and clinicians.
Author | : Osquel M. Barroso Herrera |
Publisher | : |
Total Pages | : |
Release | : 2003 |
Genre | : |
ISBN | : |
Download Manipulation of Antigen-specific T Cell Responses by Modified Dendritic Cells Book in PDF, ePub and Kindle
Author | : Gerald J. Prud'homme |
Publisher | : Springer |
Total Pages | : 149 |
Release | : 2005-07-13 |
Genre | : Medical |
ISBN | : 9780306479915 |
Download Gene Therapy of Autoimmune Disease Book in PDF, ePub and Kindle
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Author | : Lauren M. Sompayrac |
Publisher | : John Wiley & Sons |
Total Pages | : 160 |
Release | : 2015-10-26 |
Genre | : Medical |
ISBN | : 1118997778 |
Download How the Immune System Works Book in PDF, ePub and Kindle
How the Immune System Works has helped thousands of students understand what’s in their big, thick, immunology textbooks. In his book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject. In fifteen easy-to-read chapters, featuring the humorous style and engaging analogies developed by Dr. Sompayrac, How the Immune System Works explains how the immune system players work together to protect us from disease – and, most importantly, why they do it this way. Rigorously updated for this fifth edition, How the Immune System Works includes the latest information on subjects such as vaccines, the immunology of AIDS, and cancer. A highlight of this edition is a new chapter on the intestinal immune system – currently one of the hottest topics in immunology. Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject. But don’t take our word for it! Read what students have been saying about this classic book: "What an exceptional book! It's clear you are in the hands of an expert." "Possibly the Best Small Text of All Time!" "This is a FUN book, and Lauren Sompayrac does a fantastic job of explaining the immune system using words that normal people can understand." "Hands down the best immunology book I have read... a very enjoyable read." "This is simply one of the best medical textbooks that I have ever read. Clear diagrams coupled with highly readable text make this whole subject easily understandable and engaging." Now with a brand new website at www.wiley.com/go/sompayrac featuring Powerpoint files of the images from the book
Author | : Robert C. Rees |
Publisher | : Oxford University Press, USA |
Total Pages | : 469 |
Release | : 2014 |
Genre | : Medical |
ISBN | : 0199676860 |
Download Tumor Immunology and Immunotherapy Book in PDF, ePub and Kindle
Tumor immunology and immunotherapy provides a comprehensive account of cancer immunity and immunotherapy. Examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines, this book provides insight into how these problems may be overcome as viewed by leaders in the field.
Author | : Michael B. A. Oldstone |
Publisher | : Springer Science & Business Media |
Total Pages | : 166 |
Release | : 2006-01-09 |
Genre | : Medical |
ISBN | : 3540307915 |
Download Molecular Mimicry: Infection Inducing Autoimmune Disease Book in PDF, ePub and Kindle
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Author | : Manzoor M. Khan |
Publisher | : Springer Science & Business Media |
Total Pages | : 275 |
Release | : 2008-12-19 |
Genre | : Medical |
ISBN | : 0387779760 |
Download Immunopharmacology Book in PDF, ePub and Kindle
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
Author | : Bharat B. Aggarwal |
Publisher | : Springer |
Total Pages | : 489 |
Release | : 2014-05-12 |
Genre | : Medical |
ISBN | : 3034808372 |
Download Inflammation and Cancer Book in PDF, ePub and Kindle
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.