Activation Of Viruses By Host Proteases PDF Download
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| Author | : Eva Böttcher-Friebertshäuser |
| Publisher | : Springer |
| Total Pages | : 337 |
| Release | : 2018-05-22 |
| Genre | : Medical |
| ISBN | : 3319754742 |
Download Activation of Viruses by Host Proteases Book in PDF, ePub and Kindle
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.
| Author | : Uwe Lendeckel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 139 |
| Release | : 2009-06-19 |
| Genre | : Medical |
| ISBN | : 9048123488 |
Download Viral Proteases and Antiviral Protease Inhibitor Therapy Book in PDF, ePub and Kindle
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
| Author | : Robert G. Webster |
| Publisher | : John Wiley & Sons |
| Total Pages | : 684 |
| Release | : 2014-01-06 |
| Genre | : Medical |
| ISBN | : 111863683X |
Download Textbook of Influenza Book in PDF, ePub and Kindle
The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: • Influenza Perspectives • Structure and Replication • Evolution and Ecology • Epidemiology and Surveillance • Immunology • Vaccines and Vaccine Development • Clinical Aspects and Antivirals • Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.
| Author | : Rogier Willem Sanders |
| Publisher | : Amsterdam University Press |
| Total Pages | : 342 |
| Release | : 2003-12-01 |
| Genre | : Medical |
| ISBN | : 9789053566671 |
Download The HIV-1 Envelope Glycoproteins Book in PDF, ePub and Kindle
The need for a vaccine against HIV is obvious, but the development of an effective vaccine has met with frustrations. The HIV envelope glycoproteins, residing in the viral membrane, are the sole viral proteins exposed on the outside of virus particles and.
| Author | : Matthias Gotte |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2018-02-12 |
| Genre | : Medical |
| ISBN | : 9781493906932 |
Download Handbook of Antimicrobial Resistance Book in PDF, ePub and Kindle
While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.
| Author | : Charles H. Calisher |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 244 |
| Release | : 1999-08-03 |
| Genre | : Medical |
| ISBN | : 9783211833841 |
Download 100 Years of Virology Book in PDF, ePub and Kindle
Comprises papers of Dr Ursula Hoff, including correspondence and photographs, relating to her study of Charles Conder.
| Author | : Pawel Zmora |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2015 |
| Genre | : |
| ISBN | : |
Download Activation of the Influenza Virus Hemagglutinin by Type II Transmembrane Serine Proteases Book in PDF, ePub and Kindle
The influenza virus hemagglutinin (HA) mediates viral entry into target cells. HA is synthesized as an inactive precursor and depends on proteolytic processing by host cell proteases to become active. TMPRSS2, a member of the type II transmembrane serine protease (TTSP) family, can cleave and activate HA in cell culture and was recently shown to be essential for spread and pathogenesis of influenza viruses of the H1N1 subtype in mice. In contrast, an H3N2 influenza virus was less dependent on TMPRSS2, implying that this virus may hijack other TTSPs for its activation. Moreover, studies with ...
| Author | : Bindhu Hosuru |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2023 |
| Genre | : |
| ISBN | : |
Download 'Arms Race' Between Viral Proteases and the Host Immune System Book in PDF, ePub and Kindle
Viruses with a positive-sense single-stranded RNA genome [(+)ssRNA] encode proteases that antagonize the host immune system. Examples include picornaviruses, flaviviruses, and coronaviruses. The proteases they encode cleave not only key host proteins but also process viral polyproteins. Due to their dual role of cleaving numerous polyprotein sites as well as diverse host proteins, viral proteases' evolution is highly constrained. In spite of the strong evolutionary constraint, evidence suggests that viral proteases are engaged in a molecular 'arms race' with host proteins. Examples of such proteases include picornavirus 3C, flavivirus NS2B/NS3, and coronavirus 3CL. When proteases successfully cleave host proteins, it puts evolutionary pressure on the protein to escape viral antagonism. As a response, viral proteases undergo evolution to antagonize the newly evolved protein keeping its constraints in mind. Both these cases help explain why these evolutionary conflicts result in diverse protease-host interactions. It contributes to existing scientific findings on the pathogenicity of viral infection in hosts. Such examples highlight the importance of examining viral protease-host interactions through an evolutionary lens.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 607 |
| Release | : 2003-12-18 |
| Genre | : Medical |
| ISBN | : 0080493831 |
Download The Flaviviruses: Detection, Diagnosis and Vaccine Development Book in PDF, ePub and Kindle
Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research. Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions Descibes the technologies that have contributed to our current knowledge about the Flaviviruses Identifies the major problems faced in understanding the virus-host interactins that result in disease An exhaustive compendium of current and past knowledge on the Flavivirus family
| Author | : Ellen G. Strauss |
| Publisher | : Elsevier |
| Total Pages | : 476 |
| Release | : 2007-09-21 |
| Genre | : Medical |
| ISBN | : 0080553168 |
Download Viruses and Human Disease Book in PDF, ePub and Kindle
Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text
