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AC Electroosmosis for Lab-on-chip Applications

AC Electroosmosis for Lab-on-chip Applications
Author: Nazmul Islam
Publisher:
Total Pages: 121
Release: 2007
Genre:
ISBN:

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AC electrokinetics is the study of particle and fluid motion induced by AC electric fields. In the last decade it has received increasing interest due to its important applications in micro total analysis systems and miniaturized biomedical devices. With the application of very low voltage (~1V[subscript rms]), AC electrokinetics can be utilized to control and manipulate particles and fluids at the micro/nano scale, which are very difficult to achieve with existing techniques, such as pressure driven flow. Through the interaction of ac electric fields and particles/fluids, ac electrokinetics can be used to sort, separate and filter particles, and to pump and mix fluids. AC electrokinetics can operate at relatively low voltages, which is suitable for integrated lab-on-a-chip systems. This research investigates AC electroosmosis for manipulating nanofluids/ particles with an aim to provide a generic platform for the transport and concentration functions in microfluidic devices. It is envisioned that these concepts can be integrated with life science and biomedical technologies to develop a new generation of labs-on-a-chip, with high-efficiency particle manipulation and sensing, micropumps and microfluidic mixers. Two topics are studied in this thesis. One is the trapping/concentration of colloidal and bio-particles. Particle trapping is conducted adjacent to an electrolyte/electrode interface of the gold (Au) electrode pair. We have developed the capability to integrate AC electroosmotic trap and micro-cantilever (MC) in a microfluidic system. By combining both experimental investigation and theoretical analysis, this research work demonstrates a microcantilever particle trap. The second topic is the transport/mixing of fluids. An original biased AC electroosmotic pump is being developed, and experiments have been performed to prove the concept. Both numerical simulation and pumping experiment is done to optimize the pumping efficiency. The control of the biased AC-EO pumping is also suggested by using the feedback loop. The thesis concludes with suggestions on how the concepts can be exploited for the development of new strategies for colloidal separation, manipulation for microfluidics and bioMEMS technologies.


Microelectromechanical Systems and Devices

Microelectromechanical Systems and Devices
Author: Nazmul Islam
Publisher: BoD – Books on Demand
Total Pages: 496
Release: 2012-03-28
Genre: Science
ISBN: 9535103067

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The advances of microelectromechanical systems (MEMS) and devices have been instrumental in the demonstration of new devices and applications, and even in the creation of new fields of research and development: bioMEMS, actuators, microfluidic devices, RF and optical MEMS. Experience indicates a need for MEMS book covering these materials as well as the most important process steps in bulk micro-machining and modeling. We are very pleased to present this book that contains 18 chapters, written by the experts in the field of MEMS. These chapters are groups into four broad sections of BioMEMS Devices, MEMS characterization and micromachining, RF and Optical MEMS, and MEMS based Actuators. The book starts with the emerging field of bioMEMS, including MEMS coil for retinal prostheses, DNA extraction by micro/bio-fluidics devices and acoustic biosensors. MEMS characterization, micromachining, macromodels, RF and Optical MEMS switches are discussed in next sections. The book concludes with the emphasis on MEMS based actuators.


Micro/Nano Technology Systems for Biomedical Applications

Micro/Nano Technology Systems for Biomedical Applications
Author: Chih-Ming Ho
Publisher: Oxford University Press
Total Pages: 471
Release: 2010-03-25
Genre: Mathematics
ISBN: 0199219699

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A collection of chapters, authored by leading experts in the field, on the use of micro and nano technologies for biomedical applications.


Micro/Nano-Chip Electrokinetics, Volume III

Micro/Nano-Chip Electrokinetics, Volume III
Author: Xiangchun Xuan
Publisher: MDPI
Total Pages: 228
Release: 2021-02-24
Genre: Science
ISBN: 3036500480

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Micro/nanofluidics-based lab-on-a-chip devices have found extensive applications in the analysis of chemical and biological samples over the past two decades. Electrokinetics is the method of choice in these micro/nano-chips for transporting, manipulating, and sensing various analyte species (e.g., ions, molecules, fluids, and particles). This book aims to highlight the recent developments in the field of micro/nano-chip electrokinetics, ranging from the fundamentals of electrokinetics to the applications of electrokinetics to both chemo- and bio-sample handling.


Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B
Author:
Publisher: Academic Press
Total Pages: 370
Release: 2022-01-28
Genre: Science
ISBN: 0323853048

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Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B, Volume 187 represents the collation of chapters written by eminent scientists worldwide. Chapters in this new release include Design and fabrication of microfluidics devices for molecular biology applications, Micro/Nanofluidics devices for drug delivery, From organ-on-chip to body-on-chip: the next generation of microfluidics platforms for in vitro drug toxicity testing, Micro/Nanofluidics for high throughput drug screening, Design, fabrication and assembly of lab-on-a-chip and its uses, Advances in microfluidic 3D cell culture for pre-clinical drug development, Tissue and organ culture on lab-on-a chip for biomedical applications, and much more. Offers a basic understanding of the state-of-the-art design and fabrication of microfluidics/ nanofluidics and lab on chip Explains how to develop microfluidics/nanofluidic for advanced application such as healthcare, high throughout drug screening, 3D cell culture and organ-on-chip Discusses the emerging demands and research of micro/nanofluidic based devices in biomedical and translational research applications


Micro/Nano-Chip Electrokinetics

Micro/Nano-Chip Electrokinetics
Author: Xiangchun Xuan
Publisher: MDPI
Total Pages: 203
Release: 2018-07-04
Genre: Technology & Engineering
ISBN: 3038424528

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This book is a printed edition of the Special Issue "Micro/Nano-Chip Electrokinetics" that was published in Micromachines


Rotation of Spherical Microparticles in Linearly Polarized AC Electric Field

Rotation of Spherical Microparticles in Linearly Polarized AC Electric Field
Author: Md. Walid Rezanoor
Publisher:
Total Pages:
Release: 2015
Genre:
ISBN:

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The particle spin rate observed from the experimental study is then validated with a numerical model. The model is formulated around Laplace equation to determine the electric potential distribution in the domain. Stokes equation is employed to solve for AC electroosmotic fluid flow in the domain. Complexity arising from nonlinear potential drop across the electric double layer (EDL) due to the application of a very large electric potential is also addressed by introducing modified capacitance equation which considers steric effect. This method is useful in determining unknown dielectric property of microparticles / biological cells in a laboratory setting using limited resources and a simple microfluidic device.


Microtechnology for Cell Manipulation and Sorting

Microtechnology for Cell Manipulation and Sorting
Author: Wonhee Lee
Publisher: Springer
Total Pages: 287
Release: 2016-10-05
Genre: Technology & Engineering
ISBN: 3319441396

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This book delves into the recent developments in the microscale and microfluidic technologies that allow manipulation at the single and cell aggregate level. Expert authors review the dominant mechanisms that manipulate and sort biological structures, making this a state-of-the-art overview of conventional cell sorting techniques, the principles of microfluidics, and of microfluidic devices. All chapters highlight the benefits and drawbacks of each technique they discuss, which include magnetic, electrical, optical, acoustic, gravity/sedimentation, inertial, deformability, and aqueous two-phase systems as the dominant mechanisms utilized by microfluidic devices to handle biological samples. Each chapter explains the physics of the mechanism at work, and reviews common geometries and devices to help readers decide the type of style of device required for various applications. This book is appropriate for graduate-level biomedical engineering and analytical chemistry students, as well as engineers and scientists working in the biotechnology industry.


Encyclopedia of Thermal Packaging, Set 1: Thermal Packaging Techniques (a 6-Volume Set)

Encyclopedia of Thermal Packaging, Set 1: Thermal Packaging Techniques (a 6-Volume Set)
Author: Avram Bar-Cohen
Publisher: World Scientific
Total Pages: 1582
Release: 2012-02-01
Genre: Technology & Engineering
ISBN: 9814313785

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Packaging, the physical design and implementation of electronic systems is responsible for much of the progress in miniaturization, reliability and functional density achieved by the full range of electronic, microelectronic and nanoelectronic products during the past several decades. The inherent inefficiency of electronic devices and their sensitivity to heat have placed thermal management on the critical path of nearly every organization dealing with traditional electronic product development, as well as emerging, product categories. Successful thermal packaging is the key differentiator in electronic products, as diverse as supercomputers and cell phones, and continues to be of critical importance in the refinement of traditional products and in the development of products for new applications.The Encyclopedia of Thermal Packaging, compiled into four 5-volume sets (Thermal Packaging Techniques, Thermal Packaging Configurations, Thermal Packaging Tools and Thermal Packaging Applications), will provide comprehensive, one-stop treatment of the techniques, configurations, tools and applications of electronic thermal packaging. Each volume in a set comprises 250–350 pages and is written by world experts in thermal management of electronics.


Encyclopedia Of Thermal Packaging - Set 1: Thermal Packaging Techniques (A 6-volume Set)

Encyclopedia Of Thermal Packaging - Set 1: Thermal Packaging Techniques (A 6-volume Set)
Author:
Publisher: World Scientific
Total Pages: 1582
Release: 2012-09-25
Genre: Technology & Engineering
ISBN: 9814452599

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remove This Encyclopedia comes in 3 sets. To check out Set 2 and Set 3, please visit Set 2: Thermal Packaging Tools and Set 3: Thermal Packaging Applications /remove Thermal and mechanical packaging — the enabling technologies for the physical implementation of electronic systems - are responsible for much of the progress in miniaturization, reliability, and functional density achieved by electronic, microelectronic, and nanoelectronic products during the past 50 years. The inherent inefficiency of electronic devices and their sensitivity to heat have placed thermal packaging on the critical path of nearly every product development effort in traditional, as well as emerging, electronic product categories.Successful thermal packaging is the key differentiator in electronic products, as diverse as supercomputers and cell phones, and continues to be of pivotal importance in the refinement of traditional products and in the development of products for new applications. The Encyclopedia of Thermal Packaging, compiled in multi-volume sets (Set 1: Thermal Packaging Techniques, Set 2: Thermal Packaging Tools, Set 3: Thermal Packaging Applications, and Set 4: Thermal Packaging Configurations) will provide a comprehensive, one-stop treatment of the techniques, tools, applications, and configurations of electronic thermal packaging. Each of the author-written sets presents the accumulated wisdom and shared perspectives of a few luminaries in the thermal management of electronics.Set 1: Thermal Packaging TechniquesThe first set of the Encyclopedia, Thermal Packaging Techniques, focuses on the technology “building blocks” used to assemble a complete thermal management system and provide detailed descriptions of the underlying phenomena, modeling equations, and correlations, as well as guidance for achieving the optimal designs of individual “building blocks” and their insertion in the overall thermal solution. Specific volumes deal with microchannel coolers, cold plates, immersion cooling modules, thermoelectric microcoolers, and cooling devices for solid state lighting systems, as well as techniques and procedures for the experimental characterization of thermal management components. These “building blocks” are the essential elements in the creation of a complete, cost-effective thermal management system.The four sets in the Encyclopedia of Thermal Packaging will provide the novice and student with a complete reference for a quick ascent on the thermal packaging ';learning curve,'; the practitioner with a validated set of techniques and tools to face every challenge, and researchers with a clear definition of the state-of-the-art and emerging needs to guide their future efforts. This encyclopedia will, thus, be of great interest to packaging engineers, electronic product development engineers, and product managers, as well as to researchers in thermal management of electronic and photonic components and systems, and most beneficial to undergraduate and graduate students studying mechanical, electrical, and electronic engineering.